PTP Inhibitor IV: sc-222225. Immunofluorescence staining of methanol-fixed lambda protein phosphatase (sc-200312A) treated (A,B) and PTP Inhibitor IV treated (B) NIH/3T3 cells showing nuclear localization and chemical inactivation of lambda phosphatase. Antibody tested: p-NFκB p50 (A-8): sc-271908.
PTP Inhibitor IV (CAS 329317-98-8)
See product citations (4)
Alternate Names:
bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene; Protein Tyrosine Phosphatase Inhibitor IV
Application:
PTP Inhibitor IV is a potent, reversible, competitive, & active-site directed inhibitor of PTP
CAS Number:
329317-98-8
Purity:
≥95%
Molecular Weight:
608.61
Molecular Formula:
C26H26F6N2O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PTP Inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic which acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases. PTP Inhibitor IV is an inhibitor of PTP beta, PTP epsilon, PTP mu, PTP sigma, PTP-MEG, PTP1B and SH-PTP2.
PTP Inhibitor IV (CAS 329317-98-8) References
- Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. | Huang, P., et al. 2003. Bioorg Med Chem. 11: 1835-49. PMID: 12659770
- Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. | Shao, W., et al. 2005. Am J Physiol Cell Physiol. 289: C248-56. PMID: 15788487
- PTP inhibitor IV protects JNK kinase activity by inhibiting dual-specificity phosphatase 14 (DUSP14). | Park, JE., et al. 2009. Biochem Biophys Res Commun. 387: 795-9. PMID: 19646420
- The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration. | Galvao, J., et al. 2018. Invest Ophthalmol Vis Sci. 59: 2736-2747. PMID: 29860460
- Eriocitrin attenuates ischemia reperfusion-induced oxidative stress and inflammation in rats with acute kidney injury by regulating the dual-specificity phosphatase 14 (DUSP14)-mediated Nrf2 and nuclear factor-κB (NF-κB) pathways. | Xu, J., et al. 2021. Ann Transl Med. 9: 350. PMID: 33708977
Inhibitor of:
PTP beta, PTP epsilon, PTP mu, PTP sigma, PTP-MEG, PTP1B, and SH-PTP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTP Inhibitor IV, 10 mg | sc-222225 | 10 mg | $176.00 |