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PTP Inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic which acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases. PTP Inhibitor IV is an inhibitor of PTP β, PTP ε, PTP μ, PTP σ, PTP-MEG, PTP1B and SH-PTP2.
1. Huang, Ping., et al., 2003. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorganic & medicinal chemistry. 11(8): 1835-49. PMID: 12659770
2. Shao, Weijian., et al., 2005. Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American journal of physiology. Cell physiology. 289(2): C248-56. PMID: 15788487
See how others have used PTP Inhibitor IV. Click on the entry to view the PubMed entry .
PMID: # 23314616 Kim, EJ. et al. 2013. Inflammation research : official journal of the European Histamine Research Society .. [et al.]. 62: 377-86.
PMID: # 22288587 Lee, SM. et al. 2012. Clinical and experimental immunology. 167: 438-46.
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