PTP Inhibitor III (CAS 29936-81-0)

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Alternate Names: α-Bromo-4-(carboxymethoxy)acetophenone

Application: PTP Inhibitor III is a cell-permeable compound that inhibits a broad-range of PTPs

CAS Number: 29936-81-0

Purity: ≥90%

Molecular Weight: 273.1

Molecular Formula: C₁₀H₉BrO₄

Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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PTP Inhibitor III: sc-222224. Immunofluorescence staining of methanol-fixed lambda protein...

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PTP inhibitor III is a cell-permeable compound that inhibits a broad-range of PTPs (protein tyrosine phosphatases). PTPs help balance the activation of signaling proteins in vascular cells and keep the cells functioning in a normal state. The compound binds with a higher affinity to the catalytic domain of the SH2 domain-containing phosphatase SHP-1 than the PTP I inhibitor.

References

1. Kanda, M., et al. 2006. J. Biol. Chem. 281: 28518-28528. PMID: 16893901
2. Popov, D. 2009. Biochem. Biophys. Res. Commun. 389: 1-4. PMID: 19715673

Physical State :

Solid

Solubility :

Soluble in DMSO.

Storage :

Store at -80° C

IC50 :

PTP: IC₅₀ = 193 µM

Ki Data :

SHP-1: K_i= 193 µM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Transport :

UN 1759, Class 8, Packing group II

MDL Number :

MFCD01087714

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Certificate of Analysis

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PTP Inhibitor III (CAS 29936-81-0) Product Citations

See how others have used PTP Inhibitor III (CAS 29936-81-0). Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 29708510 Ubil, E. et al. 2018. J. Clin. Invest. 128: 2356-2369.

PMID: # 23314616 Kim, EJ. et al. 2013. Inflammation research : official journal of the European Histamine Research Society .. [et al.]. 62: 377-86.

PMID: # 22288587 Lee, SM. et al. 2012. Clinical and experimental immunology. 167: 438-46.

PMID: # 22571339 Kim, JK. et al. 2012. Cancer investigation. 30: 364-71.

PMID: # 22403793 Annaba, F. et al. 2012. American journal of physiology. Gastrointestinal and liver physiology. 302: G1216-22.

PMID: # 21536801 Lee, SM. et al. 2011. Journal of immunology (Baltimore, Md. : 1950). 186: 6296-303.

PMID: # 21896016 Lee, SM. et al. 2011. Immunology. 134: 224-33.

PMID: # 20646006 Lee, SM. et al. 2010. Clinical and experimental immunology. 161: 504-11.

PMID: # 22043923 Immunology. 226-35.

Citations 1 to 9 of 9 total

Rated 5 out of 5 by SM from PTP Inhibitor III was found to inhibit the PTP Inhibitor III was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated NIH/3T3 cells. -SCBT QC

Date published: 2015-02-24

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