Molecular structure of PTP Inhibitor III, CAS Number: 29936-81-0
PTP Inhibitor III (CAS 29936-81-0)
See product citations (9)
Alternate Names:
α-Bromo-4-(carboxymethoxy)acetophenone
Application:
PTP Inhibitor III is a cell-permeable compound that inhibits a broad-range of PTPs
CAS Number:
29936-81-0
Purity:
≥90%
Molecular Weight:
273.1
Molecular Formula:
C10H9BrO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PTP inhibitor III is a cell-permeable compound that inhibits a broad-range of PTPs (protein tyrosine phosphatases). PTPs help balance the activation of signaling proteins in vascular cells and keep the cells functioning in a normal state. The compound binds with a higher affinity to the catalytic domain of the SH2 domain-containing phosphatase SHP-1 than the PTP I inhibitor.
PTP Inhibitor III (CAS 29936-81-0) References
- Glutaredoxin modulates platelet-derived growth factor-dependent cell signaling by regulating the redox status of low molecular weight protein-tyrosine phosphatase. | Kanda, M., et al. 2006. J Biol Chem. 281: 28518-28. PMID: 16893901
- Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction. | Popov, D. 2009. Biochem Biophys Res Commun. 389: 1-4. PMID: 19715673
- Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK). | Lee, SM., et al. 2010. Clin Exp Immunol. 161: 504-11. PMID: 20646006
- Synthetic peptides containing ITIM-like sequences of IREM-1 inhibit BAFF-mediated regulation of interleukin-8 expression and phagocytosis through SHP-1 and/or PI3K. | Lee, SM., et al. 2011. Immunology. 134: 224-33. PMID: 21896016
- CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. | Kim, EJ., et al. 2012. Immunology. 135: 226-35. PMID: 22043923
- Synthetic peptides containing ITIM-like sequences of IREM-1 (CD300F) differentially regulate MyD88 and TRIF-mediated TLR signalling through activation of SHP and/or PI3K. | Lee, SM., et al. 2012. Clin Exp Immunol. 167: 438-46. PMID: 22288587
- Synthetic peptides containing ITIM-like domains block expression of inflammatory mediators and migration/invasion of cancer cells through activation of SHP-1 and PI3K. | Kim, JK., et al. 2012. Cancer Invest. 30: 364-71. PMID: 22571339
- SHPS-1 and a synthetic peptide representing its ITIM inhibit the MyD88, but not TRIF, pathway of TLR signaling through activation of SHP and PI3K in THP-1 cells. | Kim, EJ., et al. 2013. Inflamm Res. 62: 377-86. PMID: 23314616
- Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats. | Xiao, X., et al. 2015. Pain. 156: 597-608. PMID: 25790452
- Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition. | Su, TH., et al. 2015. Proc Natl Acad Sci U S A. 112: 7243-8. PMID: 26039995
- The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1. | Ding, CH., et al. 2018. Mol Cancer. 17: 63. PMID: 29466992
- Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. | Ubil, E., et al. 2018. J Clin Invest. 128: 2356-2369. PMID: 29708510
- Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma. | Saraswati, S., et al. 2019. Cell Commun Signal. 17: 127. PMID: 31619257
Inhibitor of:
PTP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTP Inhibitor III, 10 mg | sc-222224 | 10 mg | $282.00 |