PTP Inhibitor II CAS: 2632-13-5
MF: C9H9BrO2
MW: 229.1
A cell-permeable, covalent and potent protein tyrosine phosphatase inhibitor.

PTP Inhibitor II (CAS 2632-13-5)

PTP Inhibitor II | CAS 2632-13-5 is rated 5.0 out of 5 by 1.
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Synonym: 2-Bromo-4′-methoxyacetophenone
Application: A cell-permeable, covalent and potent protein tyrosine phosphatase inhibitor
CAS Number: 2632-13-5
Purity: ≥97%
Molecular Weight: 229.1
Molecular Formula: C9H9BrO2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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PTP inhibitor II is a cell-permeable, covalent and potent PTP (protein tyrosine phosphatase) inhibitor. The compound acts by binding the catalytic domain of the SH2 domain-containing phosphatase SHP-1(DSH2). PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Ki = 128 μM and Ki = 43 μM respectively) (sc-204220). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm. PTP inhibitors have demonstrated enhanced clonogenic survival, mutagenesis and cell growth. PTP inhibitors can also be useful for probing signal transduction pathways as well as drugs for treatment of PTP-related diseases. PTP Inhibitor II is an inhibitor of PTP1B and SH-PTP1.


References

1. Xie, J. and Seto, C.T. 2007. Bioorg. Med. Chem. 15: 458-473. PMID: 17046267
2. Park, J.E., et al. 2009. Biochem. Biophys. Res. Commun. 387: 795-799. PMID: 19646420
3. Bae, D., et al. 2009. Cell. Signal. 21: 727-736. PMID: 19167484

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO, water (partly miscible), most organic solvents, and methanol.
Storage :
Store at 4° C
Melting Point :
69-72° C
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Glycogen synthase kinase-3 beta: IC50 = 1µM (human)
Ki Data :
SHP-1 : Ki= 128 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
4965
MDL Number :
MFCD00000201
EC Number :
220-118-8
Beilstein Registry :
743112
SMILES :
COC1=CC=C(C=C1)C(=O)CBr

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Certificate of Analysis

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Rated 5 out of 5 by from Bae Bae, D. et al. (PubMed 19167484) reported that enhanced clonogenic survival induced by PTP Inhibitor II after Cr(VI) exposure is mediated by c-Raf and Ras activity. -SCBT Publication Review
Date published: 2015-06-18
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