PTP Inhibitor I CAS: 2491-38-5
MF: C8H7BrO2
MW: 215.04
A potent covalent inhibitor of protein tyrosine phosphatases SHP-1 and PTPIB.

PTP Inhibitor I (CAS 2491-38-5)

PTP Inhibitor I | CAS 2491-38-5 is rated 5.0 out of 5 by 1.
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Synonym: 4-Hydroxyphenacyl bromide; α-Bromo-4-hydroxyacetophenone
Application: A potent covalent inhibitor of protein tyrosine phosphatases SHP-1 and PTPIB
CAS Number: 2491-38-5
Purity: ≥98%
Molecular Weight: 215.04
Molecular Formula: C8H7BrO2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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PTP Inhibitor I is a potent covalent inhibitor of protein tyrosine phosphatases. The compound is found to be cell-permeable and to specifically inhibit SH-PTP1 (SHP-1) and PTP1B (Protein tyrosine phosphatase 1B). It has been observed in human ovarian cancer cells when SHP-1 is inhibited anti-tumor activity is induced. Inhibition of PTPIB has been observed to upregulate the insulin receptor signal transduction pathway. Although PTP inhibitors would prove useful for elucidating PTP signal transduction, selective active site binding has been shown to be difficult to achieve. PTP inhibitor I is utilized in laboratories as a derivatization reagent for High Performance Liquid Chromatography analysis of carboxylic acids.


References

1. Jensen, C.D., et al. 2003. Am. J. Contact Dermatitis. 14: 41-43. PMID: 14744423
2. Bishop, A.C., et al. 2007. Methods. 42: 278-288. PMID: 17532515
3. Inada, S., et al. 2007. Mol. Cell. Endocrinol. 271: 64-70. PMID: 17509747
4. Caron, D., et al. 2008. Cancer Lett. 262: 265-275. PMID: 18234419

Usage :
Unstable in DMSO; reconstitute just prior to use.
Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in chloroform, DMSO (200 mg/ml), methanol, and water (partly miscible).
Storage :
Store at -80° C
Melting Point :
123-126° C
Boiling Point :
~338.7° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
Ki Data :
SHP-1: Ki= 43 µM; PTPIB: Ki= 42 µM
pK Values :
pKa: 7.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4964
MDL Number :
MFCD00072424
EC Number :
219-655-0
SMILES :
OC1=CC=C(C=C1)C(=O)CBr

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Certificate of Analysis

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PTP Inhibitor I  Product Citations

See how others have used PTP Inhibitor I. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 28332308  Ueshima, C. et al. 2017. Cancer Med. 6: 845-856.

PMID: # 20337577  Scott, LM. et al. 2010. Curr. Pharm. Des. 16: 1843-1862.

PMID: # 19519384  Blaskovich, MA. et al. 2009. Curr. Med. Chem. 16: 2095-2176.

PMID: # 14706066  Hinton, SD. et al. 2003 Oct-Dec. Dev. Growth Differ. 45: 405-415.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from PTP Inhibitor I prevents lambda protein phosphatase PTP Inhibitor I prevents lambda protein phosphatase from de-phosphorylating p-NFkB p50. This is demonstrated by IF when an increase in nuclear localization and signal when comparing lambda protein phosphatase treated NIH/3T3 cells with those that have been treated with both lambda protein phosphatase and PTP Inhibitor I. -SCBT QC
Date published: 2015-04-06
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