PTH-rP Antibody (1D1): sc-53936

PTH-rP Antibody (1D1) is a mouse monoclonal IgG1 antibody that detects PTH-rP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PTH-rP (1D1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The parathyroid hormone-related protein (PTH-rP) plays a crucial role in regulating endochondral bone development and is involved in epithelial-mesenchymal interactions, particularly during the formation of mammary glands and teeth. Unlike parathyroid hormone (PTH), which is exclusively synthesized by parathyroid cells, PTH-rP is produced by a variety of cell types, highlighting diverse physiological roles. PTH-rP is particularly significant in humoral hypercalcemia of malignancy, where PTH-rP mimics PTH effects, leading to elevated calcium levels in the blood. Both PTH and PTH-rP are influenced by vitamin D and steroid hormones, and exert effects by binding to specific PTH/PTH-rP receptors, subsequently activating signaling pathways such as adenylate cyclase or phospholipase C beta via protein kinase C activation. PTH-rP′s ability to regulate calcium metabolism and involvement in critical developmental processes make PTH-rP an important target for research and therapeutic applications.

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PTH-rP Antibody (1D1) References:

1. Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys.  |  Brommage, R., et al. 1999. J Clin Endocrinol Metab. 84: 3757-63. PMID: 10523026
2. A parathyroid-hormone-related-protein (PTH-rP)-specific cytotoxic T cell response induced by in vitro stimulation of tumour-infiltrating lymphocytes derived from prostate cancer metastases, with epitope peptide-loaded autologous dendritic cells and low-dose IL-2.  |  Correale, P., et al. 2001. Br J Cancer. 85: 1722-30. PMID: 11742494
3. Regional mapping of the parathyroid hormone gene (PTH) by cytogenetic and molecular studies.  |  Tonoki, H., et al. 1991. Cytogenet Cell Genet. 56: 103-4. PMID: 1672845
4. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.  |  Mangin, M., et al. 1988. Proc Natl Acad Sci U S A. 85: 597-601. PMID: 2829195
5. PTH-rP and PTH-R1 Expression in Placentas from Pregnancies Complicated by Gestational Diabetes: New Insights into the Pathophysiology of Hyperglycemia in Pregnancy.  |  Sirico, A., et al. 2021. Diagnostics (Basel). 11: PMID: 34441291
6. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.  |  Suva, LJ., et al. 1987. Science. 237: 893-6. PMID: 3616618
7. Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro.  |  Horiuchi, N., et al. 1987. Science. 238: 1566-8. PMID: 3685994
8. Human parathyroid hormone: amino-acid sequence of the amino-terminal residues 1-34.  |  Brewer, HB., et al. 1972. Proc Natl Acad Sci U S A. 69: 3585-8. PMID: 4509319
9. Isolation of human parathyroid hormone.  |  O'Riordan, JL., et al. 1971. Endocrinology. 89: 234-9. PMID: 5092521
10. Parathyroid hormone: regulation of synthesis and secretion.  |  Watson, PH. and Hanley, DA. 1993. Clin Invest Med. 16: 58-77. PMID: 8467581
11. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.  |  Lanske, B., et al. 1996. Science. 273: 663-6. PMID: 8662561
12. Parathyroid hormone-related protein and hypercalcemia.  |  Rankin, W., et al. 1997. Cancer. 80: 1564-71. PMID: 9362423

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PTH-rP Antibody (1D1) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-PTH-rP Antibody (1D1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PTH-rP Antibody (1D1) Specifications

Alternate Product Name: PTHLH

Product Clone Name: 1D1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: PTH-rP

Epitope Species: human

Product Reactivity/Detection: PTH-rP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for PTH-rP Antibody (1D1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin