PtdIns-(4,5)-P2 (1,2-dipamitoyl)-d62 (sodium salt)

PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62, sodium salt, is a vital component of cellular membranes and a key player in intracellular signaling pathways. This compound, labeled with deuterium (^2H), serves as a valuable tool in elucidating lipid-mediated signaling mechanisms in research. Phosphatidylinositol 4,5-bisphosphate (PIP2) is synthesized by phosphorylation of phosphatidylinositol (PI) by PI 4-kinase and PI 5-kinase enzymes. PIP2 acts as a substrate for various enzymes, including phospholipase C (PLC), which cleaves PIP2 into two secondary messengers: inositol trisphosphate (IP3) and diacylglycerol (DAG). These secondary messengers regulate numerous cellular processes, such as calcium release from intracellular stores, protein kinase activation, cytoskeletal rearrangements, and vesicle trafficking. By utilizing PtdIns-(4,5)-P2 (1,2-dipalmitoyl)-d62, researchers can track the turnover and localization of PIP2 in cells and tissues using mass spectrometry-based lipidomics approaches. Additionally, studies employing this stable isotope-labeled lipid enable the investigation of PIP2 metabolism, lipid-protein interactions, and the impact of lipid alterations on cellular function in both normal and pathological conditions. This compound contributes to advancing our understanding of lipid signaling pathways and their implications in health and disease, offering valuable insights into potential targets for various disorders associated with dysregulated lipid signaling.