PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt)

PtdIns-(4,5)-P2 (1,2-dipalmitoyl) (sodium salt) is a phosphatidylinositol derivative and synthetic mimic of phosphatidylinositol 4,5-bisphosphate (PIP2), a pivotal lipid molecule in cellular signaling. It serves as a substrate for phosphoinositide-specific phospholipase C (PI-PLC), which hydrolyzes it into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). This process plays a key role in calcium signaling and activation of protein kinase C. Additionally, PIP2 is crucial for recruiting and activating proteins containing pleckstrin homology (PH) domains to cellular membranes, where they participate in regulating the actin cytoskeleton, membrane trafficking, and signal transduction. In research, PtdIns-(4,5)-P2 (1,2-dipalmitoyl) is used to study the structural requirements for PIP2-mediated recruitment of cytoskeletal and membrane-associated proteins and to investigate its role in the spatial organization of signaling microdomains. It helps explain the dynamics of lipid-protein interactions and is valuable for probing the role of phosphoinositide metabolism in membrane ruffling, cell migration, and intracellular trafficking. By serving as a tool to analyze PIP2-related cellular functions, this compound provides insight into the regulation of phosphoinositide pathways, aiding in the understanding of signal transduction and cytoskeletal dynamics across various experimental models.