PtdIns-(3,4,5)-P3 (1-stearoyl, 2-docosahexaenoyl) (sodium salt)
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Phosphatidyl inositol trisphosphate (PtdIns-(3,4,5)-P3) is a membrane phospholipid that may be cleaved by phospholipase C (PLC) to produce the second messengers inositol tetrakisphosphate (IP4) and diacylglycerol (DAG). IP4 triggers an increase in intracellular calcium. PtdIns-(3,4,5)-P3 (1-stearoyl, 2-docosahexaenoyl is an uncommon phospholipid having the ω-3 fatty acid docosahexaenoate (DHA) in the sn-2 position. In addition to releasing an unusual DHA-containing DAG in response to PLC, this phospholipid can serve as a source of DHA in response to phospholipases A2 (PLA2). Importantly, the inositol head group of PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of proteins bearing pleckstrin homology (PH) domains
PtdIns-(3,4,5)-P3 (1-stearoyl, 2-docosahexaenoyl) (sodium salt) References
- Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. | Ferguson, KM., et al. 2000. Mol Cell. 6: 373-84. PMID: 10983984
- Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides. | Lemmon, MA. and Ferguson, KM. 2001. Biochem Soc Trans. 29: 377-84. PMID: 11497993
- Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel. | Lückhoff, A. and Clapham, DE. 1992. Nature. 355: 356-8. PMID: 1309941
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PtdIns-(3,4,5)-P3 (1-stearoyl, 2-docosahexaenoyl) (sodium salt), 50 µg | sc-358751 | 50 µg | $144.00 | |||
PtdIns-(3,4,5)-P3 (1-stearoyl, 2-docosahexaenoyl) (sodium salt), 100 µg | sc-358751A | 100 µg | $274.00 |