PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) (CAS 1628353-02-5)

PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt), a phosphatidylinositol derivative, is pivotal in scientific research as a phospholipid involved in cell signaling. It mimics phosphatidylinositol 3,4,5-triphosphate (PIP3), a crucial intracellular signaling molecule generated by the phosphorylation of PIP2 via phosphoinositide 3-kinase (PI3K). As a direct ligand of pleckstrin homology (PH) domains, this synthetic analog is instrumental in studying the PI3K/Akt signaling pathway, which governs cell growth, survival, metabolism, and proliferation. By activating downstream signaling molecules such as Akt (protein kinase B), PtdIns-(3,4,5)-P3 modulates diverse cellular processes, facilitating the exploration of complex signal transduction mechanisms. Researchers employ this compound to investigate lipid-protein interactions, helping explain the recruitment and activation of proteins at cell membranes. It serves as a probe to dissect the functional roles of specific PH domain-containing proteins in intracellular signal transduction and to map the spatial and temporal dynamics of lipid signaling in live cells. This compound enables scientists to dissect the involvement of PI3K-dependent pathways in cell migration, cytoskeletal rearrangement, and membrane trafficking. It is indispensable in delineating the molecular underpinnings of PI3K-mediated signal transduction, providing insights into fundamental cellular processes and their broader biological implications.