Molecular structure of PTA2 (Pinane thromboxane A2), CAS Number: 71111-01-8
PTA2 (Pinane thromboxane A2) (CAS 71111-01-8)
Alternate Names:
15(S)-Pinane Thromboxane A2; Pinane TXA2
Application:
PTA2 (Pinane thromboxane A2) is a TXA2R antagonist and an inhibitor of TBXAS1
CAS Number:
71111-01-8
Molecular Weight:
376.5
Molecular Formula:
C24H40O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PTA2 (Pinane thromboxane A2) is a chemically stable, carbocyclic analog of the highly unstable thromboxane A2. PTA2 may act to act as a TXA2R antagonist which leads to coronary artery contraction and platelet aggregation induced by prostaglandin endoperoxide analogs and arachidonic acid (sc-200770). This product has also been shown to inhibit TXA Synthase (thromboxane synthase) and protects ischemic myocardium.
PTA2 (Pinane thromboxane A2) (CAS 71111-01-8) References
- Structural specificity for prostaglandin effects on hepatocyte glycogenolysis. | Brass, EP. and Garrity, MJ. 1990. Biochem J. 267: 59-62. PMID: 2158311
- Competitive antagonism at thromboxane receptors in human platelets. | Armstrong, RA., et al. 1985. Br J Pharmacol. 84: 595-607. PMID: 2580580
- Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets. | Kajikawa, N., et al. 1989. Arzneimittelforschung. 39: 495-9. PMID: 2665758
- Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. | Nicolaou, KC., et al. 1979. Proc Natl Acad Sci U S A. 76: 2566-70. PMID: 288046
- Protective effects of a novel thromboxane analog in lethal traumatic shock. | Lefer, AM., et al. 1979. Prostaglandins Med. 3: 139-46. PMID: 552102
- Thromboxane synthetase inhibitors differentially antagonize thromboxane receptors in vascular smooth muscle. | Smith, EF., et al. 1981. Naunyn Schmiedebergs Arch Pharmacol. 318: 130-4. PMID: 6276789
- Pinane thromboxane A2 analogues are non-selective prostanoid antagonists in rat and human stomach muscle. | Bennett, A. and Sanger, GJ. 1982. Br J Pharmacol. 77: 591-6. PMID: 6758907
- Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues. | Burke, SE., et al. 1983. Br J Pharmacol. 78: 287-92. PMID: 6831115
- Anti-thromboxane A2 actions of pinane thromboxane A2 derivatives. | Roth, DM., et al. 1982. Prostaglandins Leukot Med. 9: 503-9. PMID: 6960376
- Synthesis of stable thromboxane A2 analogs: pinane thromboxane A2 (PTA2) and carbocyclic thromboxane A2 (CTA2). | Nicolaou, KC. and Magolda, RL. 1982. Methods Enzymol. 86: 400-9. PMID: 7132765
- Renal effects of pinane-thromboxane A2 and indomethacin in saline volume-expanded spontaneously hypertensive rats. | Shibouta, Y., et al. 1982. Eur J Pharmacol. 85: 51-9. PMID: 7151863
- Preservation of ischemic myocardium by pinane thromboxane A2. | Schrör, K., et al. 1980. Am J Physiol. 238: H87-92. PMID: 7356037
- Role of thromboxane and angiotensin in cyclosporine-induced renal vasoconstriction in the dog. | Carrier, M., et al. 1993. J Heart Lung Transplant. 12: 851-5. PMID: 8241227
Inhibitor of:
TXA Synthase, and TXA2R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTA2 (Pinane thromboxane A2), 1 mg | sc-201177 | 1 mg | $200.00 |