Molecular structure of Psychosine, CAS Number: 2238-90-6
Psychosine (CAS 2238-90-6)
See product citations (5)
Alternate Names:
1-β-D-Galactosylsphingosine; Sphingosyl-β-D-galactopyranoside
Application:
Psychosine is a cationic lysosphingolipid that displays neuroprotective effects against quisqualate
CAS Number:
2238-90-6
Purity:
≥95%
Molecular Weight:
461.63
Molecular Formula:
C24H47NO7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Psychosine is a cationic lysosphingolipid endogenous to nervous tissues. It has been found to inhibit metabotropic alpha 1-adrenergic receptor signaling-induced phospholipase C activation in rat brain astrocytes. It has shown protective effects against quisqualate.
Psychosine (CAS 2238-90-6) References
- Synthesis of biotinylated glycoconjugates and their use in a novel ELISA for direct comparison of HIV-1 Gp120 recognition of GalCer and related carbohydrate analogues. | McReynolds, KD., et al. 1999. Bioconjug Chem. 10: 1021-31. PMID: 10563771
- Molecular mechanism of psychosine-induced cell death in human oligodendrocyte cell line. | Haq, E., et al. 2003. J Neurochem. 86: 1428-40. PMID: 12950451
- Psychosine-induced apoptosis in a mouse oligodendrocyte progenitor cell line is mediated by caspase activation. | Zaka, M. and Wenger, DA. 2004. Neurosci Lett. 358: 205-9. PMID: 15039117
- Psychosine-induced apoptosis and cytokine activation in immune peripheral cells of Krabbe patients. | Formichi, P., et al. 2007. J Cell Physiol. 212: 737-43. PMID: 17458901
- Psychosine-induced alterations in peroxisomes of twitcher mouse liver. | Contreras, MA., et al. 2008. Arch Biochem Biophys. 477: 211-8. PMID: 18602885
- Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard. | Jiang, X., et al. 2009. J Lipid Res. 50: 162-72. PMID: 18753677
- Psychosine induces the dephosphorylation of neurofilaments by deregulation of PP1 and PP2A phosphatases. | Cantuti-Castelvetri, L., et al. 2012. Neurobiol Dis. 46: 325-35. PMID: 22326830
- Psychosine cytotoxicity in rat neural cell cultures and protection by phorbol ester and dimethyl sulfoxide. | Sugama, S., et al. 1990. Pediatr Res. 28: 473-6. PMID: 2255570
- MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology. | Ijichi, K., et al. 2013. Glia. 61: 765-77. PMID: 23404611
- Quantification of psychosine in the serum of twitcher mouse by LC-ESI-tandem-MS analysis. | Zanfini, A., et al. 2013. J Pharm Biomed Anal. 80: 44-9. PMID: 23523865
- Psychosine, the cytotoxic sphingolipid that accumulates in globoid cell leukodystrophy, alters membrane architecture. | Hawkins-Salsbury, JA., et al. 2013. J Lipid Res. 54: 3303-11. PMID: 24006512
- Glycosynthase mediated synthesis of psychosine. | Goddard-Borger, ED., et al. 2016. Carbohydr Res. 435: 97-99. PMID: 27721144
- Psychosine, a marker of Krabbe phenotype and treatment effect. | Escolar, ML., et al. 2017. Mol Genet Metab. 121: 271-278. PMID: 28579020
- Psychosine remodels model lipid membranes at neutral pH. | Zulueta Díaz, YLM., et al. 2018. Biochim Biophys Acta Biomembr. 1860: 2515-2526. PMID: 30267657
- Psychosine blocks quisqualate-induced glutamate excitotoxicity in hippocampal CA sector neurons. | Hodgson, DM., et al. 1998. Brain Res. 802: 1-8. PMID: 9748472
Activator of:
GPR68.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Psychosine, 1 mg | sc-202781 | 1 mg | $100.00 | |||
Psychosine, 5 mg | sc-202781A | 5 mg | $360.00 |