Molecular structure of PSN 375963 hydrochloride, CAS Number: 388575-52-8
PSN 375963 hydrochloride (CAS 388575-52-8)
Application:
PSN 375963 hydrochloride is an agonist of the GPR119 receptor
CAS Number:
388575-52-8
Purity:
>98%
Molecular Weight:
321.84
Molecular Formula:
C17H23N3O•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
GPR119 receptor agonist (EC50 values are 8.4 and 7.9 μM at human and mouse receptors respectively). Displays similar potency to the endogenous ligand oleylethanolamide (OEA).
PSN 375963 hydrochloride (CAS 388575-52-8) References
- Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. | Overton, HA., et al. 2006. Cell Metab. 3: 167-75. PMID: 16517404
- Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players. | Lambert, DM. and Muccioli, GG. 2007. Curr Opin Clin Nutr Metab Care. 10: 735-44. PMID: 18089956
- Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. | Ning, Y., et al. 2008. Br J Pharmacol. 155: 1056-65. PMID: 18724386
- Lipid receptors and islet function: therapeutic implications? | Kebede, MA., et al. 2009. Diabetes Obes Metab. 11 Suppl 4: 10-20. PMID: 19817784
- Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses. | Cox, HM., et al. 2010. Cell Metab. 11: 532-42. PMID: 20519124
- The role of small molecule GPR119 agonist, AS1535907, in glucose-stimulated insulin secretion and pancreatic β-cell function. | Yoshida, S., et al. 2011. Diabetes Obes Metab. 13: 34-41. PMID: 21114601
- The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. | Stone, VM., et al. 2012. Br J Pharmacol. 165: 2758-70. PMID: 22029844
- Activation of GPR119 by fatty acid agonists augments insulin release from clonal β-cells and isolated pancreatic islets and improves glucose tolerance in mice. | Moran, BM., et al. 2014. Biol Chem. 395: 453-64. PMID: 24323890
- Targeting GPR119 for the potential treatment of type 2 diabetes mellitus. | Mo, XL., et al. 2014. Prog Mol Biol Transl Sci. 121: 95-131. PMID: 24373236
- PPARγ signaling and emerging opportunities for improved therapeutics. | Wang, S., et al. 2016. Pharmacol Res. 111: 76-85. PMID: 27268145
- Gadolinium induced effects on mammalian cell motility, adherence and chromatin structure. | Nagy, G., et al. 2017. Apoptosis. 22: 188-199. PMID: 27770270
- Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice. | Onodera, T., et al. 2017. Sci Rep. 7: 4560. PMID: 28676689
- 2-OMe-lysophosphatidylcholine analogues are GPR119 ligands and activate insulin secretion from βTC-3 pancreatic cells: Evaluation of structure-dependent biological activity. | Drzazga, A., et al. 2018. Biochim Biophys Acta Mol Cell Biol Lipids. 1863: 91-103. PMID: 29079451
- Effects of Obesity and Gastric Bypass Surgery on Nutrient Sensors, Endocrine Cells, and Mucosal Innervation of the Mouse Colon. | Peiris, M., et al. 2018. Nutrients. 10: PMID: 30336615
- G protein-coupled receptors expressed and studied in yeast. The adenosine receptor as a prime example. | Wang, X., et al. 2021. Biochem Pharmacol. 187: 114370. PMID: 33338473
Activator of:
GPR119.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSN 375963 hydrochloride, 10 mg | sc-204219 | 10 mg | $175.00 | |||
PSN 375963 hydrochloride, 50 mg | sc-204219A | 50 mg | $739.00 |