PSMD1 Antibody (C-7): sc-166038

PSMD1 Antibody (C-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects PSMD1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-PSMD1 antibody (C-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PSMD1, also known as proteasome (prosome, macropain) 26S subunit, non-ATPase 1, or S1/p112, plays a crucial role in selective degradation of cellular proteins, which is vital for maintaining cellular homeostasis and regulating various biological processes. PSMD1 is a key component of the 26S proteasome, a complex responsible for degradation of ubiquitinated proteins, and is primarily located in nucleus and cytoplasm of eukaryotic cells. The 26S proteasome consists of a 20S core particle that houses proteolytic activity and two 19S regulatory particles that facilitate recognition and unfolding of ubiquitinated substrates. PSMD1 is the largest of non-ATPase regulatory subunits of the 19S lid, and PSMD1′s interaction with substrates is essential for proper functioning of the proteasome, influencing processes such as cell cycle regulation, apoptosis, and response to oxidative stress. With widespread expression, particularly in skeletal muscle and heart tissues, PSMD1 is integral to cellular machinery that ensures timely removal of damaged or misfolded proteins, thereby preventing potential cellular dysfunction.

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PSMD1 Antibody (C-7) References:

1. [Investigation on NB4 cell responses to realgar by cDNA microarray].  |  Wang, HY. and Liu, SX. 2002. Zhongguo Zhong Yao Za Zhi. 27: 600-4. PMID: 12776498
2. Gene expression profile changes in NB4 cells induced by realgar.  |  Wang, H., et al. 2003. Chin Med J (Engl). 116: 1074-7. PMID: 12890387
3. Mass spectrometric analysis of expression of ATPase subunits encoded by duplicated genes in the 19S regulatory particle of rice 26S proteasome.  |  Shibahara, T., et al. 2004. Arch Biochem Biophys. 421: 34-41. PMID: 14678782
4. Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor.  |  Thompson, HG., et al. 2004. Int J Cancer. 111: 338-47. PMID: 15221960
5. Mapping of the CCK, PSMC2, PSMC4, PSMD1, CPB1 and PSPH genes in cattle.  |  Guo, H., et al. 2006. Anim Genet. 37: 73-5. PMID: 16441302
6. Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice.  |  Tan, Y., et al. 2006. J Burn Care Res. 27: 226-33. PMID: 16566573
7. Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells.  |  Wang, Z., et al. 2006. J Biol Chem. 281: 21377-21386. PMID: 16737963
8. Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics.  |  Deng, S., et al. 2007. Breast Cancer Res Treat. 104: 21-30. PMID: 17004105
9. CDNA cloning of p112, the largest regulatory subunit of the human 26s proteasome, and functional analysis of its yeast homologue, sen3p.  |  Yokota, K., et al. 1996. Mol Biol Cell. 7: 853-70. PMID: 8816993

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PSMD1 Antibody (C-7) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-PSMD1 Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PSMD1 Antibody (C-7) Specifications

Alternate Product Name: PSMD1

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 91-390

Epitope Target: PSMD1

Epitope Species: human

Product Reactivity/Detection: PSMD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for PSMD1 Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin