PSMC6 Antibody (34-Q): sc-100465

PSMC6 Antibody (34-Q) is a mouse monoclonal IgG2a kappa light chain antibody that detects PSMC6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PSMC6 antibody (34-Q) is available as a non-conjugated format. PSMC6, also known as proteasome (prosome, macropain) 26S subunit, ATPase 6, plays a crucial role in selective degradation of cellular proteins, a process vital for maintaining cellular homeostasis and regulating various cellular functions. Located within the 19S regulatory particle of the 26S proteasome, PSMC6 is one of six ATPase subunits that facilitate unfolding and translocation of ubiquitinated substrates into the proteolytic core of the proteasome. This regulatory component contains a leucine zipper motif and an AAA (ATPase associated with diverse cellular activities) domain, which are essential for function in protein degradation. Proper functioning of PSMC6 ensures damaged or misfolded proteins are efficiently removed from cells, thereby preventing potential cellular stress and maintaining overall protein quality control.

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PSMC6 Antibody (34-Q) References:

1. Activator complexes containing the proteasomal regulatory ATPases S10b (SUG2) and S6 (TBP1) in different tissues and organisms.  |  Hastings, R., et al. 1999. Mol Biol Rep. 26: 35-8. PMID: 10363644
2. A 220-kDa activator complex of the 26 S proteasome in insects and humans. A role in type II programmed insect muscle cell death and cross-activation of proteasomes from different species.  |  Hastings, RA., et al. 1999. J Biol Chem. 274: 25691-700. PMID: 10464306
3. Subcellular distribution of components of the ubiquitin-proteasome system in non-diseased human and rat brain.  |  Adori, C., et al. 2006. J Histochem Cytochem. 54: 263-7. PMID: 16148311
4. Identification of genes aberrantly expressed in mouse embryonic stem cell-cloned blastocysts.  |  Jincho, Y., et al. 2008. Biol Reprod. 78: 568-76. PMID: 17978277
5. PSMC6 promotes osteoblast apoptosis through inhibiting PI3K/AKT signaling pathway activation in ovariectomy-induced osteoporosis mouse model.  |  Zhang, Y., et al. 2020. J Cell Physiol. 235: 5511-5524. PMID: 32017075
6. Genetic variations in the PSMA6 and PSMC6 proteasome genes are associated with multiple sclerosis and response to interferon-β therapy in Latvians.  |  Paramonova, N., et al. 2021. Exp Ther Med. 21: 478. PMID: 33767773
7. The Silence of PSMC6 Inhibits Cell Growth and Metastasis in Lung Adenocarcinoma.  |  Zhang, JY., et al. 2021. Biomed Res Int. 2021: 9922185. PMID: 34239933
8. Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival.  |  Kudryashova, TV., et al. 2022. Circ Res. 130: 760-778. PMID: 35124974
9. Identification, purification, and characterization of a PA700-dependent activator of the proteasome.  |  DeMartino, GN., et al. 1996. J Biol Chem. 271: 3112-8. PMID: 8621709
10. cDNA cloning of p42, a shared subunit of two proteasome regulatory proteins, reveals a novel member of the AAA protein family.  |  Fujiwara, T., et al. 1996. FEBS Lett. 387: 184-8. PMID: 8674546
11. CADp44: a novel regulatory subunit of the 26S proteasome and the mammalian homolog of yeast Sug2p.  |  Bauer, VW., et al. 1996. Gene. 181: 63-9. PMID: 8973309
12. Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases.  |  Tanahashi, N., et al. 1998. Biochem Biophys Res Commun. 243: 229-32. PMID: 9473509