Pseurotin A (CAS 58523-30-1)
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Pseurotin A is a heterospirocyclic secondary metabolite natural product originally isolated from the culture broth of Pseudeurotium ovalis. Pseurotin A was identified as a competitive inhibitor of chitin synthase. Pseurotin A was found to induce cell differentiation of PC12 neuronal cells, indicating the compound as a tool for studying the mechanism of neurite formation. The production of immunoglobulin E (IgE) is suppressed by Pseurotin A, suggesting use as an interventional tool for studies of IgE-mediated systemic allergic response mechanisms. Pseurotin A, derived from the endophytic fungus Pseurotopsis sp., is a natural compound belonging to the pseurotin family of highly oxygenated sesquiterpenoids. Extensive research has revealed that Pseurotin A exhibits diverse biological activities such as anti-inflammatory, antioxidant, and antimicrobial properties.
Pseurotin A (CAS 58523-30-1) References
- Asymmetric total synthesis of pseurotin A. | Hayashi, Y., et al. 2003. Org Lett. 5: 2287-90. PMID: 12816430
- Synthetic studies of pseurotin A: preparation of an advanced lactam aldehyde intermediate. | Mitchell, JM. and Finney, NS. 2005. Org Biomol Chem. 3: 4274-81. PMID: 16294259
- Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus. | Maiya, S., et al. 2007. Chembiochem. 8: 1736-43. PMID: 17722120
- Cycloaspeptide A and pseurotin A from the endophytic fungus Penicillium janczewskii. | Schmeda-Hirschmann, G., et al. 2008. Z Naturforsch C J Biosci. 63: 383-8. PMID: 18669024
- Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production. | Ishikawa, M., et al. 2009. Bioorg Med Chem Lett. 19: 1457-60. PMID: 19179074
- Antiglioma pseurotin A from marine Bacillus sp. FS8D regulating tumour metabolic enzymes. | Anjum, K., et al. 2018. Nat Prod Res. 32: 1353-1356. PMID: 28641457
- Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A. | Copmans, D., et al. 2018. ACS Chem Neurosci. 9: 1652-1662. PMID: 29672015
- Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized-Induced Bone Loss by Suppressing Reactive Oxygen Species. | Chen, K., et al. 2019. Theranostics. 9: 1634-1650. PMID: 31037128
- Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor. | Abdelwahed, KS., et al. 2020. Pharmacol Res. 158: 104847. PMID: 32438039
- PCSK9 Axis-Targeting Pseurotin A as a Novel Prostate Cancer Recurrence Suppressor Lead. | Abdelwahed, KS., et al. 2021. ACS Pharmacol Transl Sci. 4: 1771-1781. PMID: 34927009
- Intra-hemocoel injection of pseurotin A from Metarhizium anisopliae, induces dose-dependent reversible paralysis in the Greater Wax Moth (Galleria mellonella). | Sbaraini, N., et al. 2022. Fungal Genet Biol. 159: 103675. PMID: 35183746
- Regulation of pseurotin A biosynthesis by GliZ and zinc in Aspergillus fumigatus. | Seo, H., et al. 2023. Sci Rep. 13: 2431. PMID: 36765124
- Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation. | Abdelwahed, KS., et al. 2023. Mar Drugs. 21: PMID: 37103355
- Novel neuritogenic activities of pseurotin A and penicillic acid. | Komagata, D., et al. 1996. J Antibiot (Tokyo). 49: 958-9. PMID: 8931737
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pseurotin A, 1 mg | sc-202300 | 1 mg | $214.00 |