Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. Pseudomonic Acid also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.
1. Fuller, A.T., et al. 1971. Nature. 234: 416-417. PMID: 5003547 2. Hughes, J. and Mellows, G. 1978. Biochem. J. 176: 305-318. PMID: 365175 3. Sutherland, R., et al. 1985. Antimicrob. Agents Chemother. 27: 495-498. PMID: 3923922
Soluble in ethanol, methanol, DMF, DMSO (≥ 10 mg/ml), and water (limited).
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Yanagisawa et alYanagisawa et al. (PubMed ID 7929087) found Pseudomonic Acid, an antibacterial agent, competitively inhibited E. coli isoleucyl-tRNA synthetase (HeRS). -SCBT Publication Review
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