Pseudomonic Acid CAS: 12650-69-0
MF: C26H44O9
MW: 500.62
An antibiotic inhibitor of isoleucyl-tRNA synthetase.

Pseudomonic Acid (CAS 12650-69-0)

Pseudomonic Acid | CAS 12650-69-0 is rated 5.0 out of 5 by 1.
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Synonym: Mupirocin; Bactroban; Mupirocine; Mupirocinum; Centany; Mupirocina; Plasimine; Bactroban Nasal
Application: An antibiotic inhibitor of isoleucyl-tRNA synthetase
CAS Number: 12650-69-0
Purity: >95%
Molecular Weight: 500.62
Molecular Formula: C26H44O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pseudomonic Acid, also known as mupirocin, is an antibiotic isolated from Pseudomonas fluorescens which strongly inhibits protein and RNA synthesis. Inhibition of protein synthesis was reversed by isoleucine and Pseudomonic Acid was shown to inhibit IleRS (isoleucyl-tRNA synthetase) in vitro. Pseudomonic Acid also demonstrates weak inhibitory action on FARSL (phenylalanyl-tRNA synthetase). Efficacy against staphylococci and streptococci including multiply resistant Staphylcoccus aureus and Staphylococcus epidermidis is reported with Pseudomonic Acid.


References

1. Fuller, A.T., et al. 1971. Nature. 234: 416-417. PMID: 5003547
2. Hughes, J. and Mellows, G. 1978. Biochem. J. 176: 305-318. PMID: 365175
3. Sutherland, R., et al. 1985. Antimicrob. Agents Chemother. 27: 495-498. PMID: 3923922

Physical State :
Solid
Derived From :
Pseudomonas fluorescens
Solubility :
Soluble in ethanol, methanol, DMF, DMSO (≥ 10 mg/ml), and water (limited).
Storage :
Store at -20° C
Melting Point :
75-78° C
Boiling Point :
~672.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
Optical Activity :
α20/D -20.1°, c = 1 in methanol
IC50 :
IleRS: IC50 = 0.8 nM (human); Nucleic Acid: IC50 = 1.60 nM
Ki Data :
Isoleucyl-tRNA synthetase: Ki= 2.5 nM (Escherichia coli)
pK Values :
pKa: 4.78 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
RA6907000
PubChem CID :
446596
Merck Index :
14: 6302
MDL Number :
MFCD01711620

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Certificate of Analysis

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Pseudomonic Acid  Product Citations

See how others have used Pseudomonic Acid. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 7929087  Yanagisawa, T. et al. 1994. J. Biol. Chem. 269: 24304-24309.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yanagisawa et al Yanagisawa et al. (PubMed ID 7929087) found Pseudomonic Acid, an antibacterial agent, competitively inhibited E. coli isoleucyl-tRNA synthetase (HeRS). -SCBT Publication Review
Date published: 2015-01-17
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