Molecular structure of Pseudohypericin, CAS Number: 55954-61-5
Pseudohypericin (CAS 55954-61-5)
Application:
Pseudohypericin is a specific inhibitor of PKC (protein kinase C) and DBH (D-β-Hydroxylase)
CAS Number:
55954-61-5
Purity:
≥98%
Molecular Weight:
520.5
Molecular Formula:
C30H16O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Pseudohypericin functions as a photosensitizer. It interacts with light to produce reactive oxygen species, leading to the destruction of targeted cells or tissues. At the molecular level, pseudohypericin absorbs light energy and transfers it to oxygen molecules, generating cytotoxic singlet oxygen species. This process induces oxidative damage and cell death in the targeted area. Pseudohypericin′s mechanism of action involves its ability to localize and accumulate in the target cells or tissues. Its unique chemical structure allows for efficient light absorption and energy transfer.
Pseudohypericin (CAS 55954-61-5) References
- Biochemical activities of extracts from Hypericum perforatum L. 5th communication: dopamine-beta-hydroxylase-product quantification by HPLC and inhibition by hypericins and flavonoids. | Denke, A., et al. 2000. Arzneimittelforschung. 50: 415-9. PMID: 10858868
- Hypericin and pseudohypericin in some Hypericum species. | Kitanov, GM. 2001. Biochem Syst Ecol. 29: 171-178. PMID: 11106845
- Phototoxic and apoptosis-inducing capacity of pseudohypericin. | Schempp, CM., et al. 2002. Planta Med. 68: 171-3. PMID: 11859473
- Antagonist effect of pseudohypericin at CRF1 receptors. | Simmen, U., et al. 2003. Eur J Pharmacol. 458: 251-6. PMID: 12504780
- Identification and quantification of hypericin and pseudohypericin in different Hypericum perforatum L. in vitro cultures. | Gadzovska, S., et al. 2005. Plant Physiol Biochem. 43: 591-601. PMID: 15979315
- Influence of the developmental stage on the (proto)-hypericin and (proto)pseudohypericin levels of Hypericum plants from Crete. | Xenophontos, M., et al. 2007. Planta Med. 73: 1309-15. PMID: 17893828
- Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction. | Hammer, KD., et al. 2008. Phytochemistry. 69: 2354-62. PMID: 18707743
- Determination of enantiomerization barriers of hypericin and pseudohypericin by dynamic high-performance liquid chromatography on immobilized polysaccharide-type chiral stationary phases and off-column racemization experiments. | Ciogli, A., et al. 2010. Chirality. 22: 463-71. PMID: 19644936
- Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. | Lavie, G., et al. 1989. Proc Natl Acad Sci U S A. 86: 5963-7. PMID: 2548193
- Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity. | Takahashi, I., et al. 1989. Biochem Biophys Res Commun. 165: 1207-12. PMID: 2558652
- Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. | Meruelo, D., et al. 1988. Proc Natl Acad Sci U S A. 85: 5230-4. PMID: 2839837
- Zafirlukast in combination with pseudohypericin attenuates spinal cord injury and motor function in experimental mice. | Chen, XG., et al. 2018. Drug Des Devel Ther. 12: 2389-2402. PMID: 30122897
- Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARS-CoV-2. | Mohamed, FF., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 35631357
- Photocytotoxic effect of pseudohypericin versus hypericin. | Vandenbogaerde, AL., et al. 1998. J Photochem Photobiol B. 45: 87-94. PMID: 9868799
Inhibitor of:
DBH, PKC, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pseudohypericin, 1 mg | sc-202777 | 1 mg | $156.00 | |||
Pseudohypericin, 5 mg | sc-202777A | 5 mg | $599.00 |