Molecular structure of PSB 1115, CAS Number: 409344-71-4
PSB 1115 (CAS 409344-71-4 (anhydrous))
See product citations (5)
Alternate Names:
1-Propyl-8-(4-sulfophenyl)xanthine potassium salt hydrate
Application:
PSB 1115 is an Adenosine A2B-R antagonist
CAS Number:
409344-71-4 (anhydrous)
Purity:
≥98%
Molecular Weight:
388.44
Molecular Formula:
C14H13N4O5SK
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PSB 1115 is a highly selective, water-soluble, human Adenosine A2B-R antagonist. Ki values are 53.4 > 10000 and > 10000 nM at human Adenosine A2B-R, Adenosine A1-R and Adenosine A3-R, respectively. This compound is also selective versus rat Adenosine A1-R and Adenosine A2A-R (Ki values are 2200 and 24000 nM, respectively). PSB 1115 is an inhibitor of Adenosine A1-R.
PSB 1115 (CAS 409344-71-4 (anhydrous)) References
- The impact of adenosine and A(2B) receptors on glucose homoeostasis. | Rüsing, D., et al. 2006. J Pharm Pharmacol. 58: 1639-45. PMID: 17331328
- A2B adenosine receptor dampens hypoxia-induced vascular leak. | Eckle, T., et al. 2008. Blood. 111: 2024-35. PMID: 18056839
- Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia. | Bilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377: 65-76. PMID: 18188542
- Adenosine A(2A) agonist and A(2B) antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation. | Michael, S., et al. 2010. Purinergic Signal. 6: 117-24. PMID: 20020217
- Assessment and characterization of purinergic contractions and relaxations in the rat urinary bladder. | Aronsson, P., et al. 2010. Basic Clin Pharmacol Toxicol. 107: 603-13. PMID: 20406212
- Adenosine A2 receptor presence and synergy with cholinergic stimulation in rabbit lacrimal gland. | Carlsson, SK., et al. 2010. Curr Eye Res. 35: 466-74. PMID: 20465439
- Detrimental effects of adenosine signaling in sickle cell disease. | Zhang, Y., et al. 2011. Nat Med. 17: 79-86. PMID: 21170046
- Impact and benefit of A(2B)-adenosine receptor agonists for the respiratory tract: mucociliary clearance, ciliary beat frequency, trachea muscle tonus and cytokine release. | Walaschewski, R., et al. 2013. J Pharm Pharmacol. 65: 123-32. PMID: 23215695
- Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms. | Schiedel, AC., et al. 2013. Purinergic Signal. 9: 351-65. PMID: 23359122
- Fibrinogen γ-Chain Peptide-Coated Adenosine 5' Diphosphate-Encapsulated Liposomes Rescue Mice From Lethal Blast Lung Injury via Adenosine Signaling. | Hagisawa, K., et al. 2016. Crit Care Med. 44: e827-37. PMID: 27054893
- The role of netrin-1 in the mouse cornea during Aspergillus fumigatus infection. | Zhou, Y., et al. 2019. Int Immunopharmacol. 71: 372-381. PMID: 30952101
- A2B adenosine receptor inhibition by the dihydropyridine calcium channel blocker nifedipine involves colonic fluid secretion. | Asano, T., et al. 2020. Sci Rep. 10: 3555. PMID: 32103051
- Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation. | Cooper, SL., et al. 2022. FASEB J. 36: e22214. PMID: 35230706
Inhibitor of:
Adenosine A1-R, Adenosine A2B-R, and CD39L1.Activator of:
CD73.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSB 1115, 10 mg | sc-203671 | 10 mg | $131.00 |