Molecular structure of PS 48, CAS Number: 1180676-32-7
PS 48 (CAS 1180676-32-7)
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Alternate Names:
(Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid
Application:
PS 48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator
CAS Number:
1180676-32-7
Molecular Weight:
286.76
Molecular Formula:
C17H15ClO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PS 48 is a PKB Kinase (phosphoinositide-dependent protein kinase-1, PDK1) activator (Kd = 10.3 muM). Studies have indicated that PS 48 selectively binds to the PIF-binding pocket of PKB Kinase (PDK1), which is a distinct region separate from the ATP binding site. PS 48 can modulate the activity of several enzymes, including cyclooxygenase-2, phospholipase A2, and nitric oxide synthase, as well as multiple transcription factors, such as NF-κB, AP-1, and STAT3. Studies have reported anti-inflammatory, anti-apoptotic, anti-oxidative, and anti-cancer properties of PS 48.
PS 48 (CAS 1180676-32-7) References
- Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. | Hindie, V., et al. 2009. Nat Chem Biol. 5: 758-64. PMID: 19718043
- Elastic network model of allosteric regulation in protein kinase PDK1. | Williams, G. 2010. BMC Struct Biol. 10: 11. PMID: 20500829
- Reprogramming of human primary somatic cells by OCT4 and chemical compounds. | Zhu, S., et al. 2010. Cell Stem Cell. 7: 651-5. PMID: 21112560
- Turning a protein kinase on or off from a single allosteric site via disulfide trapping. | Sadowsky, JD., et al. 2011. Proc Natl Acad Sci U S A. 108: 6056-61. PMID: 21430264
- Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. | Busschots, K., et al. 2012. Chem Biol. 19: 1152-63. PMID: 22999883
- Insulin augments serotonin-induced contraction via activation of the IR/PI3K/PDK1 pathway in the rat carotid artery. | Watanabe, S., et al. 2016. Pflugers Arch. 468: 667-77. PMID: 26577585
- CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency. | Wang, XQ., et al. 2017. Cell Death Differ. 24: 38-48. PMID: 27636107
- Triptolide Suppresses Glomerular Mesangial Cell Proliferation in Diabetic Nephropathy Is Associated with Inhibition of PDK1/Akt/mTOR Pathway. | Han, F., et al. 2017. Int J Biol Sci. 13: 1266-1275. PMID: 29104493
- Sendai virus-mediated transduction of mammalian spermatogonial stem cells†. | Watanabe, S., et al. 2019. Biol Reprod. 100: 523-534. PMID: 30165393
- Reversible inhibition of the blood-testis barrier protein improves stem cell homing in mouse testes. | Kanatsu-Shinohara, M., et al. 2018. J Reprod Dev. 64: 511-522. PMID: 30175719
- HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway. | Xu, WN., et al. 2019. Front Endocrinol (Lausanne). 10: 922. PMID: 32047474
- TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants. | Sun, R., et al. 2021. Cell Mol Gastroenterol Hepatol. 11: 249-272. PMID: 32827707
- PS48 promotes in vitro maturation and developmental competence of porcine oocytes through activating PI3K/Akt signalling pathway. | Jiao, Y., et al. 2020. Reprod Domest Anim. 55: 1678-1687. PMID: 32946622
- Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation. | Jin, YJ., et al. 2021. J Clin Invest. 131: PMID: 34499618
- TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway. | Zhang, S., et al. 2021. Cell Death Dis. 12: 1086. PMID: 34789718
Activator of:
Enzyme, and PKB Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PS 48, 10 mg | sc-361297 | 10 mg | $143.00 | |||
PS 48, 25 mg | sc-361297A | 25 mg | $452.00 |