PS 48 CAS: 1180676-32-7
MF: C17H15ClO2
MW: 286.76
A phosphoinositide-dependent protein kinase-1 (PDK1) activator.

PS 48 (CAS 1180676-32-7)

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Alternate Names: (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid
Application: PS 48 is a phosphoinositide-dependent protein kinase-1 (PDK1) activator
CAS Number: 1180676-32-7
Molecular Weight: 286.76
Molecular Formula: C17H15ClO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PS 48 has been shown to be a PKB Kinase (phosphoinositide-dependent protein kinase-1, PDK1) activator (Kd = 10.3 μM). Studies have indicated that this compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1). This is a distinct region separate from the ATP binding site.

Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/ml), and ethanol (50 mM).
Storage :
Store at 4° C
Boiling Point :
~444.1 °C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
pK Values :
pKa: 4.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44141940
MDL Number :
MFCD17215962
SMILES :
C1=CC=C(C=C1)/C(=CC(=O)O)/CCC2=CC=C(C=C2)Cl

Download SDS (MSDS)

Certificate of Analysis

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