Molecular structure of PS-1145 dihydrochloride, CAS Number: 431898-65-6 (free base)
PS-1145 dihydrochloride (CAS 431898-65-6 (free base))
See product citations (5)
Alternate Names:
IKK Inhibitor X
Application:
PS-1145 dihydrochloride is an IKB kinase (IKK) inhibitor
CAS Number:
431898-65-6 (free base)
Purity:
≥98%
Molecular Weight:
395.67
Molecular Formula:
C17H11ClN4O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PS-1145 dihydrochloride is in biochemistry, particularly for its role in studying the inhibition of NF-kappaB (NF-κB) activity. PS-1145 dihydrochloride is exploring the signaling pathways that involve NF-κB, a protein complex that plays a role in regulating immune response, cellular growth, and apoptosis. Some utilize PS-1145 dihydrochloride to investigate the molecular mechanisms by which NF-κB activity can be modulated, which is fundamental for understanding its impact on various cellular processes. The compound is being studied for inflammatory responses, providing insights into the regulation of genes involved in inflammation and immune function. PS-1145 dihydrochloride is in experiments aimed at understanding the role of NF-κB in stress response mechanisms within cells.
PS-1145 dihydrochloride (CAS 431898-65-6 (free base)) References
- Selective efficacy of depsipeptide in a xenograft model of Epstein-Barr virus-positive lymphoproliferative disorder. | Roychowdhury, S., et al. 2004. J Natl Cancer Inst. 96: 1447-57. PMID: 15467034
- Calcium channel blocker verapamil enhances endoplasmic reticulum stress and cell death induced by proteasome inhibition in myeloma cells. | Meister, S., et al. 2010. Neoplasia. 12: 550-61. PMID: 20651984
- Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress. | Mougiakakos, D., et al. 2011. Blood. 117: 857-61. PMID: 21030559
- Understanding the role of miRNA in regulating NF-κB in blood cancer. | Rushworth, SA., et al. 2012. Am J Cancer Res. 2: 65-74. PMID: 22206046
- Characterization of the inhibitor of kappaB kinase (IKK) complex in granulosa cell tumors of the ovary and granulosa cell tumor-derived cell lines. | Jamieson, S. and Fuller, PJ. 2013. Horm Cancer. 4: 277-92. PMID: 23674259
- Administration of IκB-kinase inhibitor PS1145 enhances apoptosis in DMBA-induced tumor in male Wistar rats. | Rajmani, RS., et al. 2015. Cell Biol Int. 39: 1317-28. PMID: 26148342
- NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma. | Verhoeven, RJ., et al. 2016. J Virol. 90: 6475-88. PMID: 27147748
- Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway. | Yang, N., et al. 2016. J Ethnopharmacol. 194: 395-402. PMID: 27566210
- Long-acting β2-agonists promote glucocorticoid-mediated repression of NF-κB by enhancing expression of the feedback regulator TNFAIP3. | Altonsy, MO., et al. 2017. Am J Physiol Lung Cell Mol Physiol. 312: L358-L370. PMID: 28039105
- Mice Deficient in Epithelial or Myeloid Cell Iκκβ Have Distinct Colonic Microbiomes and Increased Resistance to Citrobacter rodentium Infection. | Mackos, AR., et al. 2019. Front Immunol. 10: 2062. PMID: 31552024
- Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. | Cernackova, A., et al. 2019. J Neuroimmunol. 337: 577068. PMID: 31606594
- Corynebacterium tuberculostearicum, a human skin colonizer, induces the canonical nuclear factor-κB inflammatory signaling pathway in human skin cells. | Altonsy, MO., et al. 2020. Immun Inflamm Dis. 8: 62-79. PMID: 31912662
- Treatment repurposing for inflammatory bowel disease using literature-related discovery and innovation. | Kostoff, RN., et al. 2020. World J Gastroenterol. 26: 4889-4899. PMID: 32952337
Inhibitor of:
IKK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PS-1145 dihydrochloride, 5 mg | sc-301621 | 5 mg | $111.00 | |||
PS-1145 dihydrochloride, 25 mg | sc-301621A | 25 mg | $449.00 |