PRX2 Antibody (NQ-A42): sc-134426

PRX2 Antibody (NQ-A42) is a mouse monoclonal IgG2b kappa light chain antibody that detects PRX2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PRX2 antibody (NQ-A42) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. PRX2 (NQ-A42) antibody plays a crucial role in craniofacial and limb development, functioning as a transcription factor that regulates gene expression during embryogenesis. PRX2 expression is particularly significant in the cranial mesenchyme, limb buds, and branchial arches, where PRX2 contributes to the proper formation of these structures. Notably, while PRX2 is essential for development, PRX2 exhibits distinct expression patterns compared to PRX1, particularly in cardiac tissues. PRX2 is initially expressed in a diffuse myocardial pattern and later becomes localized to the ventricular septum, which is vital for heart function. Understanding the specific roles and interactions of PRX2 can provide insights into developmental disorders and potential therapeutic targets. The human PRX2 gene is located on chromosome 9q34, and PRX2 study is essential for elucidating the molecular mechanisms underlying craniofacial and limb malformations.

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PRX2 Antibody (NQ-A42) References:

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4. Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis.  |  ten Berge, D., et al. 2001. Development. 128: 2929-38. PMID: 11532916
5. Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2.  |  Lee, W., et al. 2007. J Biol Chem. 282: 22011-22. PMID: 17519234
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