PRPS1L1 Antibody (5E10): sc-517154

PRPS1L1 Antibody (5E10) is a mouse monoclonal IgG3 kappa light chain antibody that detects PRPS1L1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PRPS1L1 antibody (5E10) is available as a non-conjugated format. PRPS1L1 protein, also known as phosphoribosyl pyrophosphate synthetase 3, is primarily localized in the testis, distinguishing PRPS1L1 from other PRPS isoforms that are ubiquitously expressed. This specific localization suggests a specialized role in testicular function and spermatogenesis, where PRPS1L1 is involved in the synthesis of phosphoribosyl pyrophosphate (PRPP), a key substrate for nucleotide biosynthesis. The production of PRPP is vital for the formation of nucleotides, which are essential for DNA and RNA synthesis, thereby influencing cellular proliferation and metabolism. Mutations in the gene encoding PRPS1L1 can lead to various disorders, including Charcot-Marie-Tooth disease X-linked recessive type 5, highlighting the importance of PRPS1L1 in maintaining normal cellular functions. With proven detection capabilities across multiple species and applications, PRPS1L1 (5E10) antibody serves as a valuable tool for researchers studying nucleotide metabolism and related pathologies.

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PRPS1L1 Antibody (5E10) References:

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