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Protein Kinase Inhibitor, DMAP (CAS 938-55-6)

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Alternate Names:
N(6),N(6)-dimethyladenine
Application:
Protein Kinase Inhibitor, DMAP is a non selective inhibitor of cdc2/cyclin B
CAS Number:
938-55-6
Purity:
>98%
Molecular Weight:
163.18
Molecular Formula:
C7H9N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Protein Kinase Inhibitor, DMAP is a puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-α upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 muM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).


Protein Kinase Inhibitor, DMAP (CAS 938-55-6) References

  1. Activation of Jun N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor alpha leads to intercellular adhesion molecule-1 expression.  |  De Cesaris, P., et al. 1999. J Biol Chem. 274: 28978-82. PMID: 10506145
  2. Differential effects of 6-DMAP, olomoucine and roscovitine on Xenopus oocytes and eggs.  |  Flament, S., et al. 2000. Zygote. 8: 3-14. PMID: 10840869
  3. Potential dengue virus-triggered apoptotic pathway in human neuroblastoma cells: arachidonic acid, superoxide anion, and NF-kappaB are sequentially involved.  |  Jan, JT., et al. 2000. J Virol. 74: 8680-91. PMID: 10954569
  4. Mapping of early signaling events in tumor necrosis factor-alpha -mediated lipolysis in human fat cells.  |  Ryden, M., et al. 2002. J Biol Chem. 277: 1085-91. PMID: 11694522
  5. Development and calcium level changes in pre-implantation porcine nuclear transfer embryos activated with 6-DMAP after fusion.  |  Im, GS., et al. 2007. Mol Reprod Dev. 74: 1158-64. PMID: 17366547
  6. Apoptosis induced by an alkylated purine, 6-dimethylaminopurine, and changes in gene expression in human lymphoma U937 cells.  |  Nakashima, M., et al. 2008. Anticancer Res. 28: 609-20. PMID: 18506999
  7. Profiling drug-induced cell death pathways in the zebrafish lateral line.  |  Coffin, AB., et al. 2013. Apoptosis. 18: 393-408. PMID: 23413197
  8. 6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity.  |  Neant, I. and Guerrier, P. 1988. Exp Cell Res. 176: 68-79. PMID: 2836230
  9. Cell adhesion and gap junction formation in the early mouse embryo are induced prematurely by 6-DMAP in the absence of E-cadherin phosphorylation.  |  Aghion, J., et al. 1994. J Cell Sci. 107 (Pt 5): 1369-79. PMID: 7929642
  10. Activation of cyclin A-dependent protein kinases during apoptosis.  |  Meikrantz, W., et al. 1994. Proc Natl Acad Sci U S A. 91: 3754-8. PMID: 8170983
  11. Inhibition of protein kinases by 6-dimethylaminopurine accelerates the transition to interphase in activated mouse oocytes.  |  Szöllösi, MS., et al. 1993. J Cell Sci. 104 (Pt 3): 861-72. PMID: 8391012
  12. Alteration of cell cycle-dependent histone phosphorylations by okadaic acid. Induction of mitosis-specific H3 phosphorylation and chromatin condensation in mammalian interphase cells.  |  Ajiro, K., et al. 1996. J Biol Chem. 271: 13197-201. PMID: 8662672
  13. Inhibition of tumor necrosis factor signal transduction in endothelial cells by dimethylaminopurine.  |  Marino, MW., et al. 1996. J Biol Chem. 271: 28624-9. PMID: 8910494

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Protein Kinase Inhibitor, DMAP, 100 mg

sc-203220
100 mg
$53.00