Protein C-AAT complex Antibody (7): sc-80504
- Protein C-AAT complex Antibody (7) is a mouse monoclonal IgG1 Protein C-AAT complex antibody provided at 100 µg/ml
- raised against full length recombinant activated Protein C of human origin
- recommended for detection of a conformation-dependent epitope expressed in activated Protein C upon complex-formation with AAT of human origin by ELISA; may cross-react with non-complexed Protein C; non cross-reactive with non-complexed AAT
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Protein C-AAT complex Antibody (7). This work is in progress.
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Protein C-AAT complex Antibody (7) is a mouse monoclonal IgG1 antibody that detects Protein C-AAT complex (Protein C-AAT complex) of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-Protein C-AAT complex antibody (7) is available as the non-conjugated form. Protein C-AAT complex plays a crucial role in blood coagulation regulation, as Protein C itself is a vitamin K-dependent plasma protein synthesized in the liver, consisting of two polypeptide chains. Upon activation by thrombin bound to an endothelial surface receptor, Protein C enzymatically cleaves activated forms of coagulation Factors V and VIII, thereby inhibiting excessive blood clotting. This regulatory function maintains hemostatic balance and prevents thrombotic disorders. Protein C deficiency can lead to inherited thrombophilia, a genetic condition that significantly increases the risk of venous thrombosis and complications such as habitual abortion. The normal concentration of Protein C in human plasma is approximately 1-3 ng/ml, while the proenzyme concentration is around 3 µg/ml, highlighting Protein C′s importance in the coagulation cascade.
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Protein C-AAT complex Antibody (7) References:
- Inflammation and the activated protein C anticoagulant pathway. | Esmon, CT. 2006. Semin Thromb Hemost. 32 Suppl 1: 49-60. PMID: 16673266
- Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells. | Brueckmann, M., et al. 2006. Br J Haematol. 133: 550-7. PMID: 16681644
- Severe type I protein C deficiency with neonatal purpura fulminans due to a novel homozygous mutation in exon 6 of the protein C gene. | Abu-Amero, KK., et al. 2006. J Thromb Haemost. 4: 1152-3. PMID: 16689776
- The roles of protein C and thrombomodulin in the regulation of blood coagulation. | Esmon, CT. 1989. J Biol Chem. 264: 4743-6. PMID: 2538457
- Deficiency of protein C in congenital thrombotic disease. | Griffin, JH., et al. 1981. J Clin Invest. 68: 1370-3. PMID: 6895379
- Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism. | Dahlbäck, B. 1995. Blood. 85: 607-14. PMID: 7833465
- Mutation in blood coagulation factor V associated with resistance to activated protein C. | Bertina, RM., et al. 1994. Nature. 369: 64-7. PMID: 8164741
- Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. | Dahlbäck, B., et al. 1993. Proc Natl Acad Sci U S A. 90: 1004-8. PMID: 8430067
- Increased fetal loss in women with heritable thrombophilia. | Preston, FE., et al. 1996. Lancet. 348: 913-6. PMID: 8843809
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Protein C-AAT complex Antibody (7) | sc-80504 | 100 µg/ml | $322.00 |