Date published: 2025-11-22

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Proteasome Inhibitor I (CAS 158442-41-2)

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Alternate Names:
Z-Ile-Glu(OtBu)-Ala-Leu-CHO
Application:
Proteasome Inhibitor I is a selective inhibitor of chymotrypsin-like activities in the 26S proteasome (MCP)
CAS Number:
158442-41-2
Molecular Weight:
618.8
Molecular Formula:
C32H50N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Proteasome Inhibitor I has emerged as a cornerstone in scientific investigations, particularly within the field of cellular and molecular biology. This inhibitor operates by specifically targeting and inhibiting the activity of the proteasome, a multi-subunit protein complex responsible for the degradation of intracellular proteins. By blocking the proteolytic activity of the proteasome, Proteasome Inhibitor I enables researchers to explain the complex roles of protein degradation in cellular processes, including cell cycle regulation, apoptosis, and protein quality control. Studies utilizing Proteasome Inhibitor I have provided invaluable insights into the pathophysiology of various diseases, ranging from cancer to neurodegenerative disorders. Through its ability to perturb protein homeostasis and cellular signaling pathways, this inhibitor has facilitated the identification of novel targets and mechanisms of disease progression. Additionally, Proteasome Inhibitor I has played a crucial role in elucidating the complex interplay between proteasome function and cellular physiology, offering new avenues for understanding cellular regulation and dysfunction. Its specificity and efficacy make it an indispensable tool in deciphering the molecular mechanisms underlying fundamental biological processes and disease states, thereby advancing scientific knowledge and paving the way for future research endeavors.


Proteasome Inhibitor I (CAS 158442-41-2) References

  1. Lactacystin inhibits cathepsin A activity in melanoma cell lines.  |  Kozlowski, L., et al. 2001. Tumour Biol. 22: 211-5. PMID: 11399945
  2. Human platelet 20S proteasome: inhibition of its chymotrypsin-like activity and identification of the proteasome activator PA28. A preliminary report.  |  Ostrowska, H., et al. 2003. Platelets. 14: 151-7. PMID: 12850839
  3. Proteasome inhibitor prevents experimental arterial thrombosis in renovascular hypertensive rats.  |  Ostrowska, JK., et al. 2004. Thromb Haemost. 92: 171-7. PMID: 15213858
  4. Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.  |  Kordower, JH., et al. 2006. Ann Neurol. 60: 264-8. PMID: 16862579
  5. Proteasome inhibition and Parkinson's disease modeling.  |  Bové, J., et al. 2006. Ann Neurol. 60: 260-4. PMID: 16862585
  6. Proteasome inhibitor model of Parkinson's disease in mice is confounded by neurotoxicity of the ethanol vehicle.  |  Landau, AM., et al. 2007. Mov Disord. 22: 403-7. PMID: 17230468
  7. Persistent mitochondrial dysfunction and oxidative stress hinder neuronal cell recovery from reversible proteasome inhibition.  |  Papa, L. and Rockwell, P. 2008. Apoptosis. 13: 588-99. PMID: 18299995
  8. Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration.  |  Shin, M., et al. 2011. Neurobiol Aging. 32: 2100-2. PMID: 20018410
  9. Proteasome inhibitor-I enhances tunicamycin-induced chemosensitization of prostate cancer cells through regulation of NF-κB and CHOP expression.  |  Huong, PT., et al. 2011. Cell Signal. 23: 857-65. PMID: 21276850
  10. Degradation process of ligand-stimulated platelet-derived growth factor beta-receptor involves ubiquitin-proteasome proteolytic pathway.  |  Mori, S., et al. 1995. J Biol Chem. 270: 29447-52. PMID: 7493983
  11. A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell.  |  Figueiredo-Pereira, ME., et al. 1994. J Neurochem. 63: 1578-81. PMID: 7931314
  12. A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.  |  Traenckner, EB., et al. 1994. EMBO J. 13: 5433-41. PMID: 7957109
  13. Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.  |  Griscavage, JM., et al. 1996. Proc Natl Acad Sci U S A. 93: 3308-12. PMID: 8622934

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Proteasome Inhibitor I, 1 mg

sc-3127
1 mg
$86.00