Molecular structure of Prostaglandin I2 sodium, CAS Number: 61849-14-7
Prostaglandin I2 sodium (CAS 61849-14-7)
See product citations (3)
Alternate Names:
Prostaglandin I2 sodium is also known as Epoprostenol.
Application:
Prostaglandin I2 sodium is an eiconasoid shown to induce vasodilation and inhibit platelet aggregation.
CAS Number:
61849-14-7
Purity:
≥98%
Molecular Weight:
374.45
Molecular Formula:
C20H31O5•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandin I2 sodium (PGI2) is primarily synthesized in macrovascular endothelial cells. It may act to induce vasodilation and inhibit platelet aggregation, as well as demonstrate fibrinolytic and cytoprotective activity. Prostaglandin I2 sodium binding to the G-protein coupled IP1 receptor (PGI2 receptor) is responsible for inhibition of platelet aggregation and vasodilation activity. In addition, Prostaglandin I2 sodium greatly increases cAMP concentrations. Prostaglandin I2 sodium is 30 times more active than PGE1(sc-201223), and 10 times more active than PGD2(sc-201221) however, it is a relatively unstable eicosanoid, with a half-life of about 2 minutes under physiological conditions. Analogues such as Iloprost (sc-205349) have been developed with superior stability and similar potency for IP receptors.
Prostaglandin I,[object Object], sodium (CAS 61849-14-7) References
- Epoprostenol sodium, a prostaglandin I2, lacks tumor promoting effects in a medium-term liver carcinogenesis bioassay in rats. | Kawabe, M., et al. 2001. Cancer Lett. 162: 141-7. PMID: 11146218
- New insights into the intracellular mechanisms by which PGI2 analogues elicit vascular relaxation: cyclic AMP-independent, Gs-protein mediated-activation of MaxiK channel. | Tanaka, Y., et al. 2004. Curr Med Chem Cardiovasc Hematol Agents. 2: 257-65. PMID: 15320791
- Estrogen stimulation of COX-2-derived PGI2 confers atheroprotection. | Shah, BH. 2005. Trends Endocrinol Metab. 16: 199-201. PMID: 15950485
- Heparin-induced thrombocytopenia type II in an infant with a congenital heart defect--anticoagulation during cardiopulmonary bypass with epoprostenol sodium and heparin. | von Heymann, C., et al. 2006. Pediatr Crit Care Med. 7: 383-5. PMID: 16738494
- Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets. | Tateson, JE., et al. 1977. Prostaglandins. 13: 389-97. PMID: 191877
- Stability and microbiological properties of a new formulation of epoprostenol sodium when reconstituted and diluted. | Lambert, O., et al. 2012. Drug Des Devel Ther. 6: 61-70. PMID: 22563237
- Epoprostenol sodium for treatment of pulmonary arterial hypertension. | Saito, Y., et al. 2015. Vasc Health Risk Manag. 11: 265-70. PMID: 25999730
- Epoprostenol Therapy for Pulmonary Arterial Hypertension. | Akagi, S., et al. 2015. Acta Med Okayama. 69: 129-36. PMID: 26101188
- Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. | Weksler, BB., et al. 1977. Proc Natl Acad Sci U S A. 74: 3922-6. PMID: 333448
- Epoprostenol for the treatment of pulmonary arterial hypertension. | Cristo Ropero, MJ., et al. 2021. Expert Rev Clin Pharmacol. 14: 1005-1013. PMID: 34030557
- Droplet Size and Distribution of Nebulized 3% Sodium Chloride, Albuterol, and Epoprostenol by Phase Doppler Particle Analyzer. | McDermott, K. and Oakley, JG. 2021. Curr Ther Res Clin Exp. 94: 100623. PMID: 34306263
- International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. | Coleman, RA., et al. 1994. Pharmacol Rev. 46: 205-29. PMID: 7938166
- Endothelial nitric oxide, prostacyclin (PGI2) and tissue plasminogen activator (t-PA): alliance or neutrality? | Gryglewski, RJ. 1995. Pol J Pharmacol. 47: 467-72. PMID: 8868142
Inhibitor of:
TXA2R.Activator of:
IP Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin I2 sodium, 1 mg | sc-201231 | 1 mg | $100.00 | |||
Prostaglandin I2 sodium, 5 mg | sc-201231B | 5 mg | $417.00 | |||
Prostaglandin I2 sodium, 10 mg | sc-201231A | 10 mg | $688.00 | |||
Prostaglandin I2 sodium, 25 mg | sc-201231C | 25 mg | $1592.00 | |||
Prostaglandin I2 sodium, 100 mg | sc-201231D | 100 mg | $5824.00 | |||
Prostaglandin I2 sodium, 250 mg | sc-201231E | 250 mg | $12250.00 |