Molecular structure of Prostaglandin H1, CAS Number: 52589-22-7
Prostaglandin H1 (CAS 52589-22-7)
Alternate Names:
PGH1
Application:
Prostaglandin H1 is a COX metabolite of DGLA and the precursor to all 1-series prostaglandins and thromboxanes
CAS Number:
52589-22-7
Molecular Weight:
354.5
Molecular Formula:
C20H34O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Prostaglandin H1 (PGH1) is a COX metabolite of DGLA and the precursor to all 1-series prostaglandins and thromboxanes. PGH1 has been shown to be a suicide inhibitor of platelet TXA synthase (thromboxane synthase: Ki = 28 μM). At similar effective concentrations, yet unlike the activity of PGH2, analogs of PGH1 have been shown to have platelet aggregating activity.
Prostaglandin H1 (CAS 52589-22-7) References
- Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. | Ohki, S., et al. 1979. J Biol Chem. 254: 829-36. PMID: 104998
- Peroxidases. | O'Brien, PJ. 2000. Chem Biol Interact. 129: 113-39. PMID: 11154738
- 'Suicide' inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets. | Jones, DA. and Fitzpatrick, FA. 1990. J Biol Chem. 265: 20166-71. PMID: 2243085
- On the mechanism of prostacyclin and thromboxane A2 biosynthesis. | Hecker, M. and Ullrich, V. 1989. J Biol Chem. 264: 141-50. PMID: 2491846
- Inhibition of prostaglandin endoperoxide synthetase by thiol analogues of prostaglandin. | Ohki, S., et al. 1977. Proc Natl Acad Sci U S A. 74: 144-8. PMID: 402003
- Biological activities of prostaglandin H1 analogs. | Morita, A., et al. 1979. Prostaglandins. 18: 529-40. PMID: 531224
- Dihomogammalinolenic acid, but not eicosapentaenoic acid, activates washed human platelets. | Siess, W., et al. 1984. Biochim Biophys Acta. 801: 265-76. PMID: 6089912
- Synthetic studies on Prostanoids. XX. Synthesis of stable (+/-)-prostaglandin H1 analogs. | Sakai, K., et al. 1980. Chem Pharm Bull (Tokyo). 28: 1814-9. PMID: 7408058
- 'Suicide' inactivation of prostaglandin I2 synthase: characterization of mechanism-based inactivation with isolated enzyme and endothelial cells. | Wade, ML., et al. 1995. Arch Biochem Biophys. 321: 453-8. PMID: 7646071
- Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. | Miyamoto, T., et al. 1976. J Biol Chem. 251: 2629-36. PMID: 816795
Inhibitor of:
TXA Synthase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin H1, 25 µg | sc-205472 | 25 µg | $54.00 | |||
Prostaglandin H1, 50 µg | sc-205472A | 50 µg | $104.00 |