Prostaglandin G2 (CAS 51982-36-6)
Synonym:
PGG2
Application:
The first intermediary in the COX pathway which is stable enough to be isolated and characterized
CAS Number:
51982-36-6
Purity:
>95%
Molecular Weight:
368.5
Molecular Formula:
C20H32O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Prostaglandin G2 is the first intermediary in the COX pathway which is stable enough to be isolated and characterized - the C15 hydroperoxide of PGH2 (sc-201266). Under normal conditions, PGG2 is quickly metabolized by COX-1 and COX-2 to give PGH2, which is the main predecessor for the 2-series prostaglandins and thromboxanes - important mediators of biological functions. Prostaglandin G2 is an activator of NOS.
References
1. Kulmacz, R.J. 1987. Prostaglandins. 34: 225-240. PMID: 3118417
2. Eling, T.E., et al. 1991. J. Biol. Chem. 266: 12348-12355. PMID: 1905721
3. Liu, J., et al. 2007. J. Biol. Chem. 282: 18233-18244. PMID: 17462992
Formulation
:
A solution in acetone
Physical State
:
Liquid
Solubility
:
Soluble in DMSO (~100 mg/ml), ethanol (~100 mg/ml), and PBS (pH 7.2) (~2 mg/ml).
Storage
:
Store at -80° C
Boiling Point
:
56° C
Refractive Index
:
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany
:
1
PubChem CID
:
5280883
MDL Number
:
MFCD00036971
EC Number
:
200-662-2
SMILES
:
CCCCCC(OO)/C=C/[C@H]1C2OOC(C2)C1C/C=C\\CCCC(=O)O
Download SDS (MSDS)
Certificate of Analysis
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