Prostaglandin F2α ethyl amide (CAS 54130-36-8)
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An analog of PGF2α in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have displayed to have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs.2 Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo,2 studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr.3 PGF2α-NEt would be expected to show the typical intraocular effects of PGF2α free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
Prostaglandin F2α ethyl amide (CAS 54130-36-8) References
- The pharmacology of bimatoprost (Lumigan). | Woodward, DF., et al. 2001. Surv Ophthalmol. 45 Suppl 4: S337-45. PMID: 11434936
- The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. | Maxey, KM., et al. 2002. Surv Ophthalmol. 47 Suppl 1: S34-40. PMID: 12204699
- Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. | Bito, LZ. 1984. Exp Eye Res. 38: 181-94. PMID: 6370708
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin F2α ethyl amide, 1 mg | sc-205464 | 1 mg | $49.00 | |||
Prostaglandin F2α ethyl amide, 5 mg | sc-205464A | 5 mg | $222.00 |