Prostaglandin F2α diethyl amide
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An analog of PGF2α in which the C-1 carboxyl group has been modified to an N-diethyl amide. PG esters have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.2 Studies in our laboratories have shown that bovine and human corneal tissue convert the N-ethyl amides of various PGs to the free acids with a conversion efficiency of about 4 µg/g corneal tissue/hr.3 However, we find that dialkyl amides such as PGF2α-NEt2 are inert to corneal amidase activity, and not converted in any detectable amount to the corresponding free acids. These compounds may therefore be useful tools in elucidating the claim that PG amides have intrinsic intraocular hypotensive activity.
Prostaglandin F,[object Object], diethyl amide References
- The pharmacology of bimatoprost (Lumigan). | Woodward, DF., et al. 2001. Surv Ophthalmol. 45 Suppl 4: S337-45. PMID: 11434936
- The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. | Maxey, KM., et al. 2002. Surv Ophthalmol. 47 Suppl 1: S34-40. PMID: 12204699
- Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. | Bito, LZ. 1984. Exp Eye Res. 38: 181-94. PMID: 6370708
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin F2α diethyl amide, 1 mg | sc-224224 | 1 mg | $49.00 | |||
Prostaglandin F2α diethyl amide, 5 mg | sc-224224A | 5 mg | $225.00 |