Date published: 2025-10-17

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Prostaglandin F2α-d4 (CAS 34210-11-2)

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Alternate Names:
PGF-d4; Dinoprost-d4
Application:
Prostaglandin F2α-d4 is a PGF2αR activator
CAS Number:
34210-11-2
Purity:
≥99%
Molecular Weight:
358.51
Molecular Formula:
C20H30D4O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Prostaglandin F2α-d4, a deuterium-labeled analog of Prostaglandin F2α, is frequently in analytical studies to better understand the pharmacokinetics and metabolic pathways of prostaglandins. It serves as an internal standard in mass spectrometry due to the deuterium atoms providing a distinct mass difference that aids in the quantification and detection of the parent compound in complex biological matrices. In biochemistry, Prostaglandin F2α-d4 is used to study the role of prostaglandins in physiological processes such as inflammation and the regulation of smooth muscle contraction. Some also utilize this labeled compound to investigate the binding interactions with prostaglandin receptors and to explore signal transduction mechanisms. Prostaglandin F2α-d4 is instrumental in the development of sensitive and accurate assays for measuring prostaglandin levels in various applications, including those related to reproductive biology and the study of vascular function.


Prostaglandin F2α-d4 (CAS 34210-11-2) References

  1. Quantification of urinary 8-iso-prostaglandin F2alpha using liquid chromatography-tandem mass spectrometry during cardiac valve surgery.  |  Teng, YH., et al. 2010. J Clin Lab Anal. 24: 237-45. PMID: 20626026
  2. Prostaglandins and thromboxanes.  |  Samuelsson, B., et al. 1978. Annu Rev Biochem. 47: 997-1029. PMID: 209733
  3. The macrophage phagocytic receptor CD36 promotes fibrogenic pathways on removal of apoptotic cells during chronic kidney injury.  |  Pennathur, S., et al. 2015. Am J Pathol. 185: 2232-45. PMID: 26092500
  4. Comparing Targeted vs. Untargeted MS2 Data-Dependent Acquisition for Peak Annotation in LC-MS Metabolomics.  |  Ten-Doménech, I., et al. 2020. Metabolites. 10: PMID: 32225041
  5. Metabolomic profiling of fatty acid biomarkers for intracerebral hemorrhage stroke.  |  Zhang, J., et al. 2021. Talanta. 222: 121679. PMID: 33167285
  6. Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase.  |  Watanabe, K., et al. 1986. Proc Natl Acad Sci U S A. 83: 1583-7. PMID: 3456602
  7. Comprehensive profiling of lipid metabolites in urine of canine patients with liver mass.  |  Kida, T., et al. 2022. J Vet Med Sci. 84: 1074-1078. PMID: 35675982
  8. Prostaglandins in reproductive physiology.  |  Speroff, L. and Ramwell, PW. 1970. Am J Obstet Gynecol. 107: 1111-30. PMID: 4914185
  9. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes.  |  Crankshaw, DJ. and Gaspar, V. 1995. J Reprod Fertil. 103: 55-61. PMID: 7535849

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Prostaglandin F2α-d4, 50 µg

sc-205468
50 µg
$51.00

Prostaglandin F2α-d4, 100 µg

sc-205468A
100 µg
$130.00