Prostaglandin E2 serinol amide (CAS 951209-67-9)
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Prostaglandin E2 serinol amide (PGE2-SA) is a stable analog of the PGE2 2-glyceryl ester, which equilibrates rapidly (within minutes) to the more stable 1-glyceryl ester (sc-205453), producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media - making this compound potentially useful to probe the action of this elusive 2-glycero species. Incubation of 2-arachidonylglycerol (2-AG), the putative natural ligand for the CB1 receptor, with COX-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation. The similarity in structure between these acylmonoglycerides should prove useful in structure-activity studies used to in the deconvolution of these complex biochemical pathways.
Prostaglandin E2 serinol amide (CAS 951209-67-9) References
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- Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells. | Sugiura, T., et al. 1997. J Biochem. 122: 890-5. PMID: 9399597
- 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through CA2+-dependent and -independent mechanisms. | Kondo, S., et al. 1998. FEBS Lett. 429: 152-6. PMID: 9650580
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin E2 serinol amide, 1 mg | sc-224221 | 1 mg | $59.00 | |||
Prostaglandin E2 serinol amide, 500 µg | sc-224221A | 500 µg | $31.00 |