Date published: 2025-10-15

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Prostaglandin E2 p-benzamidophenyl ester (CAS 57790-53-1)

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Alternate Names:
PGE2 p-benzamidophenyl ester
Application:
Prostaglandin E2 p-benzamidophenyl ester is a crystalline derivative of PGE2 esterified at the carboxylic acid moiety
CAS Number:
57790-53-1
Molecular Weight:
547.7
Molecular Formula:
C33H41NO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Prostaglandin E2 p-benzamidophenyl ester is a crystalline derivative of PGE2 (sc-201225) that is esterified at the carboxylic acid moiety. PGE2 is one of the primary COX products of arachidonic acid (sc-200770), that asserts a plethora of biological activity through binding to the type E prostaglandin receptors; EP1,2,3, and 4. Selective antagonists of a particular EP receptor sub-type have been exceptionally difficult to produce, therefore structure-activity studies are important to determine the binding characteristics of PGE2 to these EP receptors in order to develop novel selective EP antagonists. Prostaglandin E2 p-acetamidophenyl ester could potentially be used in structure-activity studies to determine ways to selectively antagonize specific EP receptor sub-types.


Prostaglandin E2 p-benzamidophenyl ester (CAS 57790-53-1) References

  1. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2. Intravenous, oral and intrajejunal administration.  |  Robert, A., et al. 1976. Gastroenterology. 70: 359-70. PMID: 174967
  2. Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus.  |  Zhang, Y., et al. 2023. Ann N Y Acad Sci. 1529: 84-100. PMID: 37658670
  3. Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain threshold.  |  Willis, AL. and Cornelsen, M. 1973. Prostaglandins. 3: 353-7. PMID: 4729578
  4. Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines.  |  Arvind, P., et al. 1995. Biochemistry. 34: 5604-9. PMID: 7727422
  5. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.  |  Coleman, RA., et al. 1994. Pharmacol Rev. 46: 205-29. PMID: 7938166
  6. Cervical ripening before induction of labor: a randomized trial of prostaglandin E2 gel versus low-dose oxytocin.  |  Jackson, GM., et al. 1994. Am J Obstet Gynecol. 171: 1092-6. PMID: 7943077
  7. Hepatic metabolomic and lipidomic analyses in the Ossabaw miniature swine with diet-induced steatohepatitis: 1441[J].  |  Onjiko R M, Jannasch A S, Cooper B R,. 2012,. Hepatology,. 56:: 869A-870A.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Prostaglandin E2 p-benzamidophenyl ester, 1 mg

sc-205452
1 mg
$49.00

Prostaglandin E2 p-benzamidophenyl ester, 5 mg

sc-205452A
5 mg
$222.00