Molecular structure of Prostaglandin E2-biotinamide, CAS Number: 363-24-6 (unconjugated)
Prostaglandin E2-biotinamide (CAS 363-24-6 (unconjugated))
Application:
Prostaglandin E2-biotinamide is A biotinylated PGE2 derivative designed to detect PGE2 bound in complexes
CAS Number:
363-24-6 (unconjugated)
Molecular Weight:
662.9
Molecular Formula:
C35H58N4O6S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
The major eicosanoid product of cyclooxygenase-1 and 2 in epithelial cells, leukocytes, reproductive tissues, and many others. PGE2 contracts smooth muscle, protects the gastric mucosa, modulates immune function, and regulates fertility and implantation. PGE2 acts through at least four 7-transmembrane G-protein coupled receptors, EP1 · EP4. PGE2-biotinamide is an affinity probe that allows PGE2 to be detected through an interaction with the biotin ligand. PGE2-biotinamide was designed to allow PGE2 to be detected in complexes with transmembrane receptors and/or nucleic acid or protein binding partners. Therefore, it is a tool to be used in the general elucidation of the mechanism of action of PGs.
Prostaglandin E2-biotinamide (CAS 363-24-6 (unconjugated)) References
- Paradoxical regulation by PGE-2 on release of neutrophil chemoattractants by rat bone marrow macrophages. | Christman, JW., et al. 1991. Prostaglandins. 41: 251-62. PMID: 1852897
- Prostaglandin E2 and leukotriene C4-induced luteinizing hormone-releasing hormone release from immature and adult male rat median eminences in vitro: eicosanoid formation and binding parameters. | Gerozissis, K., et al. 1991. Prostaglandins. 41: 345-57. PMID: 1871376
- Prostaglandin E2 induced changes in renal blood flow, renal interstitial hydrostatic pressure and sodium excretion in the rat. | Long, CR., et al. 1990. Prostaglandins. 40: 591-601. PMID: 2093936
- Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release. | Raud, J., et al. 1988. Proc Natl Acad Sci U S A. 85: 2315-9. PMID: 2451246
- Delayed-onset synergism between leukotriene B4 and prostaglandin E2 in human skin. | Archer, CB., et al. 1987. Prostaglandins. 33: 799-805. PMID: 2823313
- Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. | Kuno, S., et al. 1986. Proc Natl Acad Sci U S A. 83: 3487-90. PMID: 3010301
- Sleep-wake regulation by prostaglandins D2 and E2. | Hayaishi, O. 1988. J Biol Chem. 263: 14593-6. PMID: 3049580
- Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. | Kuno, S., et al. 1986. Proc Natl Acad Sci U S A. 83: 2682-3. PMID: 3458226
- Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. | Miller, TA. 1983. Am J Physiol. 245: G601-23. PMID: 6195926
- Effect of prostaglaidin endoperoxides and metabolites on bone resorption in vitro. | Raisz, LG., et al. 1977. Nature. 267: 532-4. PMID: 876371
- The vasodilator actions of isoprenaline, histamine, prostaglandin E2, glucagon and secretin on the hepatic arterial vascular bed of the dog. | Richardson, PD. and Withrington, PG. 1976. Br J Pharmacol. 57: 581-8. PMID: 963344
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin E2-biotinamide, 50 µg | sc-222197 | 50 µg | $63.00 | |||
Prostaglandin E2-biotinamide, 100 µg | sc-222197A | 100 µg | $119.00 |