Molecular structure of Prostaglandin D2 methyl ester, CAS Number: 49852-81-5
Prostaglandin D2 methyl ester (CAS 49852-81-5)
Alternate Names:
PGD2 methyl ester
Application:
Prostaglandin D2 methyl ester is a lipid-soluble, cell-permeable PGD2 analog
CAS Number:
49852-81-5
Molecular Weight:
366.49
Molecular Formula:
C21H34O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis.1 It causes vasodilation, flushing, hypotension, and is an inhibitor of platelet aggregation.1,2 PGD2 is also produced in the brain via a soluble, secreted PGD-synthase also known as β-trace.3,4 In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.3,4 PGD2 methyl ester is a more lipid-soluble, cell-permeable prodrug form of PGD2.5 It binds to the human and murine PGD2 receptors (DP1 and CRTH2/DP2) with 5-10 fold lower affinity than PGD2.6
Prostaglandin D,[object Object], methyl ester (CAS 49852-81-5) References
- The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells. | Li, J., et al. 2003. Life Sci. 73: 1083-96. PMID: 12818718
- Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor. | Hirai, H., et al. 2003. Biochem Biophys Res Commun. 307: 797-802. PMID: 12878180
- Sleep-wake regulation by prostaglandins D2 and E2. | Hayaishi, O. 1988. J Biol Chem. 263: 14593-6. PMID: 3049580
- Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. | Onoe, H., et al. 1988. Proc Natl Acad Sci U S A. 85: 4082-6. PMID: 3163802
- The biology and pharmacology of PGD2. | Giles, H. and Leff, P. 1988. Prostaglandins. 35: 277-300. PMID: 3283848
- Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. | Suzuki, F., et al. 1987. Biochim Biophys Acta. 917: 224-30. PMID: 3467795
- Combined effects of microcystin-LR and rice straw-derived biochar on the hepatic antioxidant capacity of zebrafish: Insights from LC-MS/MS-based metabolomics analysis. | Lin, W., et al. 2023. Sci Total Environ. 904: 166830. PMID: 37673272
- Development of lipophilic anticancer agents for the treatment of brain tumors by the esterification of water-soluble chlorambucil. | Genka, S., et al. 1993. Clin Exp Metastasis. 11: 131-40. PMID: 8444006
- Diisobutylaluminum 2, 6-di-t-butyl-4-methylphenoxide. Novel stereoselective reducing agent for prostaglandin synthesis[J]. | Iguchi S, Nakai H, Hayashi M. 1981,. Bulletin of the Chemical Society of Japan,. 54(10):: 3033-3041.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin D2 methyl ester, 500 µg | sc-222194 | 500 µg | $42.00 | |||
Prostaglandin D2 methyl ester, 1 mg | sc-222194A | 1 mg | $80.00 |