Molecular structure of Propranolol hydrochloride, CAS Number: 3506-09-0
Propranolol hydrochloride (CAS 3506-09-0)
See product citations (9)
Alternate Names:
(±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
Application:
Propranolol hydrochloride is a β1 and β2 adrenergic receptor blocker
CAS Number:
3506-09-0
Purity:
≥97%
Molecular Weight:
295.80
Molecular Formula:
C16H21NO2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Propranolol hydrochloride is a cationic amphiphillic molecule shown to block beta1 and beta2 adrenergic receptors with similar efficacy, without affecting alpha adrenergic receptors. Demonstrates high affinity for SR-1B (5-HT1B) receptors (Ki = 17nM), and milder affinity for SR-1D (5HT-1D) receptors (Ki = 10.2 muM). Propranolol hydrochloride also may act to inhibit the formation of phospholipase D-derived diacylglycerol (DAG) by inhibiting cytosolic phosphatidate phosphohydrolase making propranolol a useful tool for investigating phospholipase D-, and phospholipase C-mediated DAG production. Propranolol hydrochloride is an inhibitor of AR.
Propranolol hydrochloride (CAS 3506-09-0) References
- Propranolol hydrochloride-anionic polymer binding interaction. | Takka, S. 2003. Farmaco. 58: 1051-6. PMID: 14505738
- Receptor-coupled phospholipase D and its inhibition. | Thompson, NT., et al. 1991. Trends Pharmacol Sci. 12: 404-8. PMID: 1665608
- Stability of propranolol hydrochloride in SyrSpend SF. | Geiger, CM., et al. 2012. Int J Pharm Compd. 16: 513-5. PMID: 23259369
- Topical propranolol hydrochloride gel for superficial infantile hemangiomas. | Wang, L., et al. 2012. J Huazhong Univ Sci Technolog Med Sci. 32: 923-926. PMID: 23271298
- Taste masking of propranolol hydrochloride by microbeads of EUDRAGIT® E PO obtained with prilling technique for paediatric oral administration. | Lopalco, A., et al. 2020. Int J Pharm. 574: 118922. PMID: 31836482
- Removal of propranolol hydrochloride by batch biosorption using remaining biomass of alginate extraction from Sargassum filipendula algae. | Coelho, CM., et al. 2020. Environ Sci Pollut Res Int. 27: 16599-16611. PMID: 32128732
- Bucco-Adhesive Film as a Pediatric Proper Dosage Form for Systemic Delivery of Propranolol Hydrochloride: In-vitro and in-vivo Evaluation. | Mohamad, SA., et al. 2020. Drug Des Devel Ther. 14: 4277-4289. PMID: 33116415
- Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension. | Kurćubić, I., et al. 2021. Int J Pharm. 610: 121266. PMID: 34752918
- Semisolid Extrusion 3D Printing of Propranolol Hydrochloride Gummy Chewable Tablets: an Innovative Approach to Prepare Personalized Medicine for Pediatrics. | Zhu, C., et al. 2022. AAPS PharmSciTech. 23: 166. PMID: 35705726
- Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation. | Teaima, MH., et al. 2022. Drug Deliv. 29: 2549-2560. PMID: 35912869
- Propranolol hydrochloride induces neurodevelopmental toxicity and locomotor disorders in zebrafish larvae. | Li, X., et al. 2022. Neurotoxicology. 93: 337-347. PMID: 36341947
- Propranolol-induced inhibition of rat brain cytoplasmic phosphatidate phosphohydrolase. | Pappu, AS. and Hauser, G. 1983. Neurochem Res. 8: 1565-75. PMID: 6324013
- The binding of propranolol at 5-hydroxytryptamine1D beta T355N mutant receptors may involve formation of two hydrogen bonds to asparagine. | Glennon, RA., et al. 1996. Mol Pharmacol. 49: 198-206. PMID: 8569707
- Phospholipase D is involved in cytosolic phospholipase A2-dependent selective release of arachidonic acid by fMLP-stimulated rat neutrophils. | Fujita, K., et al. 1996. FEBS Lett. 395: 293-8. PMID: 8898114
Inhibitor of:
AR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Propranolol hydrochloride, 1 g | sc-3580 | 1 g | $39.00 | |||
Propranolol hydrochloride, 5 g | sc-3580B | 5 g | $126.00 |