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Propofol β-D-glucuronide (CAS 114991-26-3)

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Alternate Names:
2,6-Bis(1-methylethyl)phenyll β-D-glucopyranosiduronic acid; Propofol Glucuronide
Application:
Propofol β-D-glucuronide is a Propofol metabolite
CAS Number:
114991-26-3
Purity:
≥98%
Molecular Weight:
354.39
Molecular Formula:
C18H26O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Propofol β-D-glucuronide ,also know as Propofol Glucuronide, is a metabolite of Propofol, an extensively studied compound in the field of biochemistry. Research on Propofol β-D-glucuronide centers on its formation and excretion as it provides insights into the metabolic pathways of its parent compound. Investigations involve analyzing the role of glucuronidation, a major phase II metabolic reaction, in the biotransformation of Propofol by the uridine 5′-diphospho-glucuronosyltransferase (UGT) enzyme family. Additionally, the compound is used to study the efficiency of detoxification processes and the subsequent renal clearance of glucuronide conjugates. Propofol β-D-glucuronide′s solubility and polarity characteristics also make it a subject of interest in research on chemical metabolism and the factors that influence the kinetic profiles of anesthetics.


Propofol β-D-glucuronide (CAS 114991-26-3) References

  1. Propofol metabolites in man following propofol induction and maintenance.  |  Favetta, P., et al. 2002. Br J Anaesth. 88: 653-8. PMID: 12067002
  2. Biosynthesis of drug glucuronides for use as authentic standards.  |  Soars, MG., et al. 2002. J Pharmacol Toxicol Methods. 47: 161-8. PMID: 12628307
  3. Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms.  |  Fujiwara, R., et al. 2007. Drug Metab Dispos. 35: 747-57. PMID: 17293379
  4. Comparison of GC/MS and LC/MS methods for the analysis of propofol and its metabolites in urine.  |  Lee, SY., et al. 2012. J Chromatogr B Analyt Technol Biomed Life Sci. 900: 1-10. PMID: 22672847
  5. Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes.  |  Chen, A., et al. 2018. Toxicol Lett. 295: 379-389. PMID: 30036684
  6. Evaluation of the inhibition risk of shikonin on human and rat UDP-glucuronosyltransferases (UGT) through the cocktail approach.  |  Cheng, Y., et al. 2019. Toxicol Lett. 312: 214-221. PMID: 31128210
  7. Mertansine Inhibits mRNA Expression and Enzyme Activities of Cytochrome P450s and Uridine 5'-Diphospho-Glucuronosyltransferases in Human Hepatocytes and Liver Microsomes.  |  Choi, WG., et al. 2020. Pharmaceutics. 12: PMID: 32131538
  8. Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays.  |  Luo, H., et al. 2020. Regul Toxicol Pharmacol. 113: 104637. PMID: 32145316
  9. Industrial Approach to Determine the Relative Contribution of Seven Major UGT Isoforms to Hepatic Glucuronidation.  |  Busse, D., et al. 2020. J Pharm Sci. 109: 2309-2320. PMID: 32294459
  10. Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug-drug interaction potentials.  |  Park, R., et al. 2021. J Toxicol Environ Health A. 84: 821-835. PMID: 34187333
  11. Untargeted Metabolomics Identify a Panel of Urinary Biomarkers for the Diagnosis of Urothelial Carcinoma of the Bladder, as Compared to Urolithiasis with or without Urinary Tract Infection in Dogs.  |  Tsamouri, MM., et al. 2022. Metabolites. 12: PMID: 35323643
  12. Toxicokinetics of β-Amanitin in Mice and In Vitro Drug-Drug Interaction Potential.  |  Bang, YY., et al. 2022. Pharmaceutics. 14: PMID: 35456608
  13. Biotransformation of Penindolone, an Influenza A Virus Inhibitor.  |  Liu, S., et al. 2023. Molecules. 28: PMID: 36771146

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Propofol β-D-glucuronide, 5 mg

sc-222192
5 mg
$498.00

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This chemical, Propofol β-D-glucuronide (CAS 114991-26-3), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-24
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Rated 5 out of 5 by from Various publications cite the use of PropofolVarious publications cite the use of Propofol -D-glucuronide, a Propofol metabolite, as a standard in the development of a liquid chromatography and mass spectroscopy bioanalytical assay for in vitro enzyme kinetics and in vivo pharmacokinetics of of glucuronides. -SCBT Publication Review
Date published: 2015-01-02
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Propofol β-D-glucuronide is rated 5.0 out of 5 by 1.
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