Propofol Glucuronide is a metabolite following rapid clearance of Propofol linked with glucuronidation by the uridine diphosphate glucuronosyltransferases. The compound has been used as a standard to develop a liquid chromatography and mass spectroscopy bioanalytical assay for in vitro enzyme kinetics and in vivo pharmacokinetics of of glucuronides.
1. Favetta, P., et al. 2002. Br J Anaesth. 88: 653-658. PMID: 12067002 2. Soars, M.G., et al. 2002. J Pharmacol Toxicol Methods. 47: 161-168. PMID: 12628307 3. Fujiwara, R., et al. 2007. Drug Metab. Dispos. 35: 747-757. PMID: 17293379
Soluble in DMSO, Ethanol and Methanol
Store at -20° C
~562.4° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.58 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
Various publications cite the use of PropofolVarious publications cite the use of Propofol -D-glucuronide, a Propofol metabolite, as a standard in the development of a liquid chromatography and mass spectroscopy bioanalytical assay for in vitro enzyme kinetics and in vivo pharmacokinetics of of glucuronides. -SCBT Publication Review
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