Date published: 2026-4-30

1-800-457-3801

SCBT Portrait Logo
Seach Input

Propionyl Glycine (CAS 21709-90-0)

5.0(1)
Write a reviewAsk a question

See product citations (2)

Alternate Names:
N-Propionylglycine
Application:
Propionyl Glycine is a methylmalonic acid and propionic acid metabolite
CAS Number:
21709-90-0
Purity:
≥97%
Molecular Weight:
131.13
Molecular Formula:
C5H9NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Propionyl Glycine is a methylmalonic acid and propionic acid metabolite. Propionylglycine (PG) is a naturally occurring amino acid that plays a vital role in the body′s metabolic pathway and is found as its anion, propionylglycinate. This component is present in various proteins and enzymes and contributes significantly to numerous biochemical and physiological processes. In scientific research, Propionyl Glycine serves as a valuable resource for laboratory experiments. Its applications encompass multiple areas, acting as a reagent for synthesizing diverse compounds like peptides and peptidomimetics. Additionally, it functions as a biochemical and physiological probe, facilitating the investigation of enzyme activity, protein-protein interactions, and other essential biological mechanisms.


Propionyl Glycine (CAS 21709-90-0) References

  1. N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides.  |  Wilcox, BJ., et al. 1999. Biochemistry. 38: 3235-45. PMID: 10079066
  2. A pathway for the biosynthesis of fatty acid amides.  |  Merkler, KA., et al. 1999. Adv Exp Med Biol. 469: 519-25. PMID: 10667377
  3. Evidence for substrate preorganization in the peptidylglycine α-amidating monooxygenase reaction describing the contribution of ground state structure to hydrogen tunneling.  |  McIntyre, NR., et al. 2010. J Am Chem Soc. 132: 16393-402. PMID: 21043511
  4. A new paradigm for known metabolite identification in metabonomics/metabolomics: metabolite identification efficiency.  |  Everett, JR. 2015. Comput Struct Biotechnol J. 13: 131-44. PMID: 25750701
  5. Expanding the phenotype in aminoacylase 1 (ACY1) deficiency: characterization of the molecular defect in a 63-year-old woman with generalized dystonia.  |  Sass, JO., et al. 2016. Metab Brain Dis. 31: 587-92. PMID: 26686503
  6. Multi-omics analysis reveals the influence of tetracycline on the growth of ryegrass root.  |  Han, T., et al. 2022. J Hazard Mater. 435: 129019. PMID: 35523093
  7. Changes in the Primary Metabolites of 'Fengtang' Plums during Storage Detected by Widely Targeted Metabolomics.  |  Lin, X., et al. 2022. Foods. 11: PMID: 36140954
  8. Metabolic and metatranscriptional characteristics of corals bleaching induced by the most severe marine heatwaves in the South China Sea.  |  Sun, F., et al. 2023. Sci Total Environ. 858: 160019. PMID: 36356778
  9. Inhibition by methylmalonate of glycine uptake by synaptosomes from rat spinal cord.  |  Lopez-Lahoya, J., et al. 1981. J Neurochem. 36: 325-7. PMID: 6109757
  10. Propionyl-CoA carboxylase deficiency: case report, effect of low-protein diet and identification of 3-oxo-2-methylvaleric acid 3-hydroxy-2-methylvaleric acid, and maleic acid in urine.  |  Bergstrøm, T., et al. 1981. Scand J Clin Lab Invest. 41: 117-26. PMID: 7313494
  11. Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric analysis of glycine conjugates and urinary isovalerylglycine in isovaleric acidemia.  |  Ito, T., et al. 1995. J Chromatogr B Biomed Appl. 670: 317-22. PMID: 8548022
  12. The Biochemistry of Ciliates in Pure Culture  |  GEORGE W. KIDDER, VIRGINIA C. DEWEY. 1951. Biochemistry and Physiology of Protozoa. 323-400.
  13. Metabolic variations of organic acids, amino acids, fatty acids and aroma compounds in the pulp of different pummelo varieties  |  Chunhua Zhu a b, Qi Lu a c, Xianyan Zhou b, Jinxue Li b, Jianqiang Yue b, Ziran Wang b, Siyi Pan a c. 2020. LWT. 130.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Propionyl Glycine, 2.5 mg

sc-212592
2.5 mg
$109.00

What is this soluble in?

Asked by: chemicalsmg
Thank you for your question. Propionyl Glycine: sc-212592 is slightly soluble in DMSO or methanol.
Answered by: Chemical Support 3
Date published: 2017-04-17
  • y_2026, m_4, d_23, h_7CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_212592, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 102ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from ItoIto, T. et al. (PubMed 8548022) were able to detect the presence of Propionyl Glycine based on its liquid chromatographic-atmospheric pressure chemical ionization mass spectra. -SCBT Publication Review
Date published: 2015-03-19
  • y_2026, m_4, d_23, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_212592, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT
Propionyl Glycine is rated 5.0 out of 5 by 1.
  • y_2026, m_4, d_23, h_7
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.43
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_212592, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 95ms
  • REVIEWS, PRODUCT