Date published: 2026-4-19

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Propionaldehyde (CAS 123-38-6)

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Alternate Names:
Propaldehyde; Methylacetaldehyde
Application:
Propionaldehyde is a laboratory chemical used in PEGylated protein purification
CAS Number:
123-38-6
Purity:
97%
Molecular Weight:
58.08
Molecular Formula:
C3H6O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Propionaldehyde, with the CAS number 123-38-6, is an organic compound known chemically as propanal. It is a colorless, flammable liquid with a pungent, slightly fruity odor, primarily used in the chemical industry as a precursor to other chemicals. Structurally, it is an aldehyde with three carbon atoms, and its chemical behavior is largely defined by the highly reactive carbonyl group attached to one of the end carbons in the chain. This aldehyde group makes propionaldehyde an important intermediate in various synthetic processes. In research, propionaldehyde has been extensively studied for its role in the synthesis of polymers, pharmaceuticals, and perfumes. Its reactivity allows it to undergo a variety of chemical reactions including aldol condensation, which is used to create larger, more complex organic molecules. It also participates in hydrogenation and oxidation reactions, which are fundamental in producing alcohols and acids, respectively. Moreover, propionaldehyde is used in the study of atmospheric chemistry where researchers investigate its photooxidation under various conditions to understand its behavior and impact in the Earth′s atmosphere. This research is crucial for modeling pollution dynamics and developing strategies to mitigate air quality degradation. Thus, propionaldehyde serves not only as a building block in industrial applications but also as a key subject in environmental scientific studies.


Propionaldehyde (CAS 123-38-6) References

  1. The effect of ethanol ingestion on the aldehyde dehydrogenases of rat liver.  |  Greenfield, NJ., et al. 1976. Biochim Biophys Acta. 428: 627-32. PMID: 1276172
  2. Kinetics of induction of cytosolic benzaldehyde: NADP and propionaldehyde: NAD aldehyde dehydrogenase activities in rat livers from male Wistar rats.  |  Ritter, E. and Eriksson, LC. 1991. Carcinogenesis. 12: 751-8. PMID: 2029738
  3. Role of water complexes in the reaction of propionaldehyde with OH radicals.  |  Vöhringer-Martinez, E., et al. 2010. J Phys Chem A. 114: 9720-4. PMID: 20507131
  4. Integrated solid-phase synthesis and purification of PEGylated protein.  |  Shang, X., et al. 2011. Biomacromolecules. 12: 2772-9. PMID: 21657227
  5. Chromatographic approaches for determination of low-molecular mass aldehydes in bio-oil.  |  Tessini, C., et al. 2012. J Chromatogr A. 1219: 154-60. PMID: 22153285
  6. The oxidation of alpha-beta unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenases.  |  Mitchell, DY. and Petersen, DR. 1987. Toxicol Appl Pharmacol. 87: 403-10. PMID: 3564015
  7. Microbial metabolism of amino alcohols. 1-Aminopropan-2-ol and ethanolamine metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas.  |  Jones, A. and Turner, JM. 1973. Biochem J. 134: 167-82. PMID: 4723219
  8. High-performance liquid chromatographic method for the simultaneous detection of malonaldehyde, acetaldehyde, formaldehyde, acetone and propionaldehyde to monitor the oxidative stress in heart.  |  Cordis, GA., et al. 1994. J Chromatogr A. 661: 181-91. PMID: 8136906
  9. Methylglyoxal as substrate and inhibitor of human aldehyde dehydrogenase: comparison of kinetic properties among the three isozymes.  |  Izaguirre, G., et al. 1998. Comp Biochem Physiol B Biochem Mol Biol. 119: 747-54. PMID: 9787766
  10. Effects of varying heptylamine and propionaldehyde plasma polymerization parameters on mesenchymal stem cell attachment  |  Sandstrom, A. M., Jasieniak, M., Griesser, H. J., Grøndahl, L., & Cooper‐White, J. J. 2013. Plasma Processes and Polymers. 10(1): 19-28.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Propionaldehyde, 250 ml

sc-250787
250 ml
$65.00