Propentofylline (CAS 55242-55-2)
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Propentofylline is a xanthine derivative that has been the focus of numerous scientific studies, especially in the field of neuroscience research. Investigations into Propentofylline often explore its role in modulating the activity of glial cells, which are for the proper functioning of the central nervous system. Researchers examine the impact of Propentofylline on the uptake and metabolism of adenosine, a neuromodulator with a significant role in neurotransmission. Additionally, due to its affinity for adenosine receptors, Propentofylline′s effects on cellular signaling pathways are scrutinized, which can lead to insights into the molecular mechanisms underlying neuroprotection and neuroplasticity. The compound is also used in studies aiming to understand cerebral blood flow.
Propentofylline (CAS 55242-55-2) References
- Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. | Bath, PM., et al. 2000. Cochrane Database Syst Rev. CD000162. PMID: 10796310
- Propentofylline protects beta-amyloid protein-induced apoptosis in cultured rat hippocampal neurons. | Koriyama, Y., et al. 2003. Eur J Pharmacol. 458: 235-41. PMID: 12504778
- Propentofylline for dementia. | Frampton, M., et al. 2003. Cochrane Database Syst Rev. CD002853. PMID: 12804440
- Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. | Sweitzer, S. and De Leo, J. 2011. Handb Exp Pharmacol. 235-50. PMID: 20859798
- Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. | Landry, RP., et al. 2012. Exp Neurol. 234: 340-50. PMID: 22119425
- Propentofylline targets TROY, a novel microglial signaling pathway. | Jacobs, VL., et al. 2012. PLoS One. 7: e37955. PMID: 22649568
- Propentofylline decreases hypothalamic astrogliosis induced by hypercaloric diet in the rat. | Bondan, EF., et al. 2018. Arq Neuropsiquiatr. 76: 252-256. PMID: 29742238
- Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale. | Sanders, O. and Rajagopal, L. 2020. J Alzheimers Dis Rep. 4: 185-215. PMID: 32715279
- Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. | Parkinson, FE., et al. 1994. Gen Pharmacol. 25: 1053-8. PMID: 7875526
- Clinical trials in dementia with propentofylline. | Kittner, B., et al. 1997. Ann N Y Acad Sci. 826: 307-16. PMID: 9329701
- Support of homeostatic glial cell signaling: a novel therapeutic approach by propentofylline. | Schubert, P., et al. 1997. Ann N Y Acad Sci. 826: 337-47. PMID: 9329704
- Propentofylline in the treatment of Alzheimer's disease and vascular dementia: a review of phase III trials. | Rother, M., et al. 1998. Dement Geriatr Cogn Disord. 9 Suppl 1: 36-43. PMID: 9716243
- Propentofylline in the treatment of vascular dementia and Alzheimer-type dementia: overview of phase I and phase II clinical trials. | Mielke, R., et al. 1998. Alzheimer Dis Assoc Disord. 12 Suppl 2: S29-35. PMID: 9769027
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Propentofylline, 25 mg | sc-208188 | 25 mg | $185.00 |