Molecular structure of Proparacaine hydrochloride, CAS Number: 5875-06-9
Proparacaine hydrochloride (CAS 5875-06-9)
Alternate Names:
Proxymetacaine hydrochloride
CAS Number:
5875-06-9
Purity:
≥99%
Molecular Weight:
330.85
Molecular Formula:
C16H26N2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Proparacaine hydrochloride is a local anesthetic that functions by blocking the voltage-gated sodium channels in the cell membrane of neurons. This action prevents the generation and conduction of action potentials, leading to the inhibition of nerve signal transmission. It acts by binding to the intracellular portion of the sodium channel, thereby stabilizing the inactive state of the channel and impeding its return to the active state. This results in the prevention of depolarization and the subsequent transmission of pain signals. In a research and development applications, proparacaine hydrochloride is utilized to study the mechanisms of neuronal signaling and to investigate the role of sodium channels in pain perception. Its mode of action at the molecular level provides insights into the functioning of the nervous system.
Proparacaine hydrochloride (CAS 5875-06-9) References
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- A single drop of 0.5% proparacaine hydrochloride for uncomplicated clear corneal phacoemulsification. | Joshi, RS. 2013. Middle East Afr J Ophthalmol. 20: 221-4. PMID: 24014985
- Non-antiepileptic drugs for trigeminal neuralgia. | Zhang, J., et al. 2013. Cochrane Database Syst Rev. CD004029. PMID: 24297506
- Degree of corneal anaesthesia after topical application of 0.4% oxybuprocaine hydrochloride and 0.5% proparacaine hydrochloride ophthalmic solution in clinically normal cattle. | Little, WB., et al. 2016. Aust Vet J. 94: 181-5. PMID: 27237118
- Proparacaine-Induced Mydriasis During Strabismus Surgery. | Takkar, B., et al. 2018. Semin Ophthalmol. 33: 367-370. PMID: 27960641
- Corneal anesthetic effect and ocular tolerance of 3.5% lidocaine gel in comparison with 0.5% aqueous proparacaine and 0.5% viscous tetracaine in normal canines. | Venturi, F., et al. 2017. Vet Ophthalmol. 20: 405-410. PMID: 27981712
- Effects of topical ophthalmic application of 0.5% proparacaine hydrochloride on aerobic bacterial culture results for naturally occurring infected corneal ulcers in dogs. | Fentiman, KE., et al. 2018. J Am Vet Med Assoc. 253: 1140-1145. PMID: 30311533
- Effects of proparacaine on actin cytoskeleton of corneal epithelium. | Dass, BA., et al. 1988. J Ocul Pharmacol. 4: 187-94. PMID: 3198982
- Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride. | Yang, Z., et al. 2020. J Pharm Biomed Anal. 190: 113497. PMID: 32798917
- New application of an old drug proparacaine in treating epilepsy via liposomal hydrogel formulation. | Taleb, A., et al. 2021. Pharmacol Res. 169: 105636. PMID: 33932606
- Age and Sex Variation in the Duration of Action and Corneal Touch Threshold (CTT) following Instillation of 0.5% Topical Ophthalmic Proparacaine and Tetracaine Hydrochlorides. | Kyei, S., et al. 2021. J Ophthalmol. 2021: 8661098. PMID: 34336260
- Dermatologic reaction in Stevens-Johnson syndrome after ophthalmic anesthesia with proparacaine hydrochloride. | Ward, B., et al. 1978. Am J Ophthalmol. 86: 133-5. PMID: 354393
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Proparacaine hydrochloride, 1 g | sc-264146 | 1 g | $63.00 |