Date published: 2026-4-23

1-800-457-3801

SCBT Portrait Logo
Seach Input

PROLI NONOate (CAS 178948-42-0)

0.0(0)
Write a reviewAsk a question

Application:
PROLI NONOate is a nitric oxide donor
CAS Number:
178948-42-0
Molecular Weight:
219.11
Molecular Formula:
C5H7N3O42Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

PROLI NONOate is a chemical compound that functions as a nitric oxide donor in experimental applications. It acts by releasing nitric oxide, which interacts with various cellular components to modulate signaling pathways and physiological processes., PROLI NONOate undergoes spontaneous decomposition to generate nitric oxide, which can activate soluble guanylate cyclase, leading to the production of cyclic guanosine monophosphate (cGMP). This, in turn, can regulate various cellular functions such as smooth muscle relaxation, neurotransmission, and immune response. Nitric oxide derived from PROLI NONOate can directly interact with proteins and enzymes, influencing their activity and function within the cell. PROLI NONOate serves as a source of nitric oxide, which plays a role in mediating cellular signaling and physiological responses in experiments.


PROLI NONOate (CAS 178948-42-0) References

  1. Nitric oxide activation of guanylyl cyclase in cells revisited.  |  Roy, B. and Garthwaite, J. 2006. Proc Natl Acad Sci U S A. 103: 12185-90. PMID: 16882726
  2. Platelet-based Detection of Nitric Oxide in Blood by Measuring VASP Phosphorylation.  |  Srihirun, S., et al. 2019. J Vis Exp.. PMID: 30663683
  3. A neuroglobin-based high-affinity ligand trap reverses carbon monoxide-induced mitochondrial poisoning.  |  Rose, JJ., et al. 2020. J Biol Chem. 295: 6357-6371. PMID: 32205448
  4. Optimization of nitric oxide donors for investigating biofilm dispersal response in Pseudomonas aeruginosa clinical isolates.  |  Cai, YM. and Webb, JS. 2020. Appl Microbiol Biotechnol. 104: 8859-8869. PMID: 32865612
  5. Antimicrobial properties of diethylamine NONOate, a nitric oxide donor, against Escherichia coli: a pilot study.  |  Sysel, AM., et al. 2021. J Antibiot (Tokyo). 74: 260-265. PMID: 33361779
  6. Genetic engineering of circularly permuted yellow fluorescent protein reveals intracellular acidification in response to nitric oxide stimuli.  |  Deng, H., et al. 2021. Redox Biol. 41: 101943. PMID: 33752109
  7. Stepwise nitrosylation of the nonheme iron site in an engineered azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins.  |  Tian, S., et al. 2021. Chem Sci. 12: 6569-6579. PMID: 34040732
  8. The Ferric-Superoxo Intermediate of the TxtE Nitration Pathway Resists Reduction, Facilitating Its Reaction with Nitric Oxide.  |  Martin, CP., et al. 2021. Biochemistry. 60: 2436-2446. PMID: 34319079
  9. Reduction of a Heme Cofactor Initiates N-Nitroglycine Degradation by NnlA.  |  Strickland, KA., et al. 2022. Appl Environ Microbiol. 88: e0102322. PMID: 35916514
  10. Modulating Nitric Oxide Dioxygenase and Nitrite Reductase of Cytoglobin through Point Mutations.  |  Ukeri, J., et al. 2022. Antioxidants (Basel). 11: PMID: 36139890
  11. Cyanide replaces substrate in obligate-ordered addition of nitric oxide to the non-heme mononuclear iron AvMDO active site.  |  York, NJ., et al. 2023. J Biol Inorg Chem. 28: 285-299. PMID: 36809458
  12. Light-driven Oxidative Demethylation Reaction Catalyzed by a Rieske-type Non-heme Iron Enzyme Stc2.  |  Hu, WY., et al. 2022. ACS Catal. 12: 14559-14570. PMID: 37168530
  13. Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor.  |  Saavedra, JE., et al. 1996. J Med Chem. 39: 4361-5. PMID: 8893830

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PROLI NONOate, 10 mg

sc-222190
10 mg
$52.00

PROLI NONOate, 50 mg

sc-222190A
50 mg
$234.00

PROLI NONOate, 100 mg

sc-222190B
100 mg
$365.00