Molecular structure of Proglumide, CAS Number: 6620-60-6
Proglumide (CAS 6620-60-6)
Alternate Names:
4-(Benzoylamino)-5-(dipropylamino)-5-oxo-pentanoic Acid; DL-4-Benzamido-N,N-dipropylglutaramic Acid; (±)-Proglumide; Binoside; CR 242; DL-4-Benzamido-N,N-dipropylglutaramic Acid; DL-Proglumide; Gastrotopic; Midelid; Milid; Milide; Nulsa; Promid; Ulcutin; W 5219; Xyde; Xylamide; Xylamide
Application:
Proglumide is An anticholinergic that exerts an inhibitory effect on gastric secretion, reduces gastrointestinal motility, and is used clinically in the drug therapy of gastrointestinal ulcers.
CAS Number:
6620-60-6
Molecular Weight:
334.41
Molecular Formula:
C18H26N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Proglumide acts as a selective antagonist of the CCK receptor, which is involved in the regulation of various physiological processes, including digestion and appetite. Proglumide has been primarily studied for its effects on the gastrointestinal system, where it inhibits the release of CCK and reduces gastric acid secretion. Proglumide is used in the synthesis of related compounds, aiding in the exploration of structure-activity relationships which are essential for the advancement of chemical sciences.
Proglumide (CAS 6620-60-6) References
- Effects of proglumide, a gastrin receptor antagonist, on human large intestine carcinoma SW480 cell line. | Shen, K., et al. 1998. Chin Med J (Engl). 111: 1075-8. PMID: 11263367
- Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions. | Fox, MA., et al. 2006. Pharmacol Biochem Behav. 84: 169-77. PMID: 16777201
- Effect of intravenous infusion of proglumide on ruminal motility in conscious sheep (Ovis aries). | Onaga, T. 2007. Vet Res Commun. 31: 1021-36. PMID: 17279465
- Ameliorating effects of proglumide on neurobehavioral and biochemical deficits in animal model of status epilepticus. | Ahmad, M. and Wadaan, MA. 2014. Pak J Pharm Sci. 27: 1945-51. PMID: 25362597
- Unsulfated CCK-8 not blocked by proglumide or CR 1409 in the mouse abdominal irritant-induced stretching assay: possible central site of action. | Ambrose, FG., et al. 1989. Peptides. 10: 31-4. PMID: 2748423
- Lack of Analgesic Synergy of the Cholecystokinin Receptor Antagonist Proglumide and Spinal Cord Stimulation for the Treatment of Neuropathic Pain in Rats. | Inoue, S., et al. 2017. Neuromodulation. 20: 534-542. PMID: 28393429
- Proglumide Reverses Nonalcoholic Steatohepatitis by Interaction with the Farnesoid X Receptor and Altering the Microbiome. | Gay, MD., et al. 2022. Int J Mol Sci. 23: PMID: 35163821
- Proglumide has access to brain and antagonizes the central satiety effect of cholecystokinin octapeptide in the dog. | Inui, A., et al. 1987. Brain Res. 417: 355-9. PMID: 3651819
- Proglumide stimulates basal pancreatic secretion in the conscious rat. | Miyasaka, K., et al. 1987. Digestion. 37: 135-43. PMID: 3653528
- The effects of the cholecystokinin antagonist, proglumide, on prolactin secretion in the rat. | Vijayan, E. and McCann, SM. 1987. Life Sci. 40: 629-34. PMID: 3807652
- Proglumide prevents and curtails acute tolerance to morphine in rats. | Tang, J., et al. 1984. Neuropharmacology. 23: 715-8. PMID: 6462377
- Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide. | Watkins, LR., et al. 1984. Science. 224: 395-6. PMID: 6546809
- The effects of proglumide on cholecystokinin-, bombesin-, and glucagon-induced satiety in the rat. | Collins, S., et al. 1983. Life Sci. 32: 2223-9. PMID: 6843294
- Effects of proglumide and enprostil on omeprazole-induced fundic endocrine cell hyperplasia in rats. | Delwaide, J., et al. 1993. Gastroenterol Clin Biol. 17: 792-6. PMID: 8143943
Inhibitor of:
CCK-AR, and CCK-BR.Activator of:
CCK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Proglumide, 1 g | sc-460085 | 1 g | $320.00 | |||
Proglumide, 25 g | sc-460085A | 25 g | $681.00 |