Proglumetacin (CAS 57132-53-3)
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Proglumetacin acts as a potent inhibitor of cyclooxygenase, targeting the COX-1 and COX-2 enzymes. This inhibition leads to a decrease in the production of prostaglandins, which are involved in the inflammatory response. By reducing prostaglandin levels, proglumetacin exerts its anti-inflammatory, analgesic, and antipyretic effects. At the molecular level, proglumetacin binds to the active site of the COX enzymes, preventing the conversion of arachidonic acid to prostaglandin H2. This disruption of the prostaglandin synthesis pathway ultimately results in the attenuation of inflammation and pain. Proglumetacin′s mechanism of action involves the specific inhibition of COX enzymes, leading to a reduction in prostaglandin production and subsequent anti-inflammatory effects.
Proglumetacin (CAS 57132-53-3) References
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- Maintenance therapy of rheumatoid arthritis and of osteoarthrosis with proglumetacin. | Bozsóky, S. and Zahumenszky, Z. 1983. Pharmatherapeutica. 3: 305-13. PMID: 6844368
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Proglumetacin, 5 mg | sc-489877 | 5 mg | $408.00 |