Molecular structure of Progabide, CAS Number: 62666-20-0
Progabide (CAS 62666-20-0)
Alternate Names:
Gabren; Gabrene; Halogabide
Application:
Progabide is a GABAA and GABAB receptor agonistic
CAS Number:
62666-20-0
Molecular Weight:
334.77
Molecular Formula:
C17H16ClFN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Progabide is an analog and prodrug of gamma-aminobutyric acid. It has potential uses in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors.
Progabide (CAS 62666-20-0) References
- Co-administration of progabide inhibits haloperidol-induced oral dyskinesias in rats. | Kaneda, H., et al. 1992. Eur J Pharmacol. 212: 43-9. PMID: 1555638
- An analysis of anticonvulsant actions of GABA agonists (progabide and baclofen) in the kindling model of epilepsy. | Sato, K., et al. 1990. Epilepsy Res. 5: 117-24. PMID: 2158438
- Neuroleptic-induced oral dyskinesias: effects of progabide and lack of correlation with regional changes in glutamic acid decarboxylase and choline acetyltransferase activities. | Mithani, S., et al. 1987. Psychopharmacology (Berl). 93: 94-100. PMID: 2888156
- The effects of progabide (SL 76002) on locomotor activity and conditioned place preference induced by d-amphetamine. | Di Scala, G., et al. 1985. Eur J Pharmacol. 107: 271-4. PMID: 2984007
- Suppression by progabide of ethanol withdrawal syndrome in rats. | Fadda, F., et al. 1985. Eur J Pharmacol. 109: 321-5. PMID: 2985405
- A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy. | Crawford, P. and Chadwick, D. 1986. J Neurol Neurosurg Psychiatry. 49: 1251-7. PMID: 3098923
- Effects of progabide on bicuculline-induced epileptic seizures in developing rats. | Mecarelli, O., et al. 1988. Clin Neuropharmacol. 11: 443-53. PMID: 3219676
- Pharmacologic probe with progabide of GABA mechanisms in essential tremor. | Koller, WC., et al. 1987. Arch Neurol. 44: 905-6. PMID: 3619708
- Progabide in the treatment of hyperkinetic extrapyramidal movement disorders. | Mondrup, K., et al. 1985. Acta Neurol Scand. 72: 341-3. PMID: 3864333
- gamma-Aminobutyric acid (GABA) receptor stimulation. II. Specificity of progabide (SL 76002) and SL 75102 for the GABA receptor. | Lloyd, KG., et al. 1982. J Pharmacol Exp Ther. 220: 672-7. PMID: 6121050
- gamma-Aminobutyric acid (GABA) receptor stimulation. I. Neuropharmacological profiles of progabide (SL 76002) and SL 75102, with emphasis on their anticonvulsant spectra. | Worms, P., et al. 1982. J Pharmacol Exp Ther. 220: 660-71. PMID: 6278129
- The potential use of GABA agonists in psychiatric disorders: evidence from studies with progabide in animal models and clinical trials. | Lloyd, KG., et al. 1983. Pharmacol Biochem Behav. 18: 957-66. PMID: 6351106
- Progabide treatment in severe epilepsy: a double-blind cross-over trial versus placebo. | Martínez-Lage, JM., et al. 1984. Epilepsia. 25: 586-93. PMID: 6383790
- The comparative effects of benzodiazepines, progabide and PK 9084 on acquisition of passive avoidance in mice. | Broekkamp, CL., et al. 1984. Psychopharmacology (Berl). 83: 122-5. PMID: 6429696
- An analysis of the actions of progabide, a specific GABA receptor agonist, on kindling and kindled seizures. | Joy, RM., et al. 1984. Exp Neurol. 83: 144-54. PMID: 6690314
Inhibitor of:
Gab 1.Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Progabide, 5 mg | sc-476638A | 5 mg | $100.00 | |||
Progabide, 100 mg | sc-476638 | 100 mg | $380.00 |