Prochlorperazine, dimaleate (CAS 84-02-6)
QUICK LINKS
Prochlorperazine, dimaleate is a compound that functions as a dopamine receptor antagonist. It acts by blocking the dopamine receptors in the brain, the D2 receptors, leading to a decrease in dopamine activity. Prochlorperazine′s mechanism of action involves inhibiting the transmission of dopamine signals, which can result in altered neurotransmitter activity. By interfering with dopamine signaling, it can impact various physiological and behavioral processes in experimental models. Prochlorperazine′s functional role in development, lies in its ability to modulate dopamine receptor activity, providing a use for investigating the role of dopamine in various biological processes. Its mechanism of action at the molecular level involves binding to and blocking dopamine receptors, thereby influencing neurotransmitter signaling pathways. Prochlorperazine′s function in experiments involves its ability to manipulate dopamine receptor activity, allowing for the study of dopamine-related processes in biological systems.
Prochlorperazine, dimaleate (CAS 84-02-6) References
- Multiple perianal ulcers due to suppositories. | Savoia, F., et al. 2019. Australas J Dermatol. 60: 50-52. PMID: 30039854
- In vitro melanogenesis inhibition by fluphenazine and prochlorperazine in normal human melanocytes lightly pigmented. | Otręba, M., et al. 2018. Daru. 26: 85-89. PMID: 30159761
- Filovirus Antiviral Activity of Cationic Amphiphilic Drugs Is Associated with Lipophilicity and Ability To Induce Phospholipidosis. | Gunesch, AP., et al. 2020. Antimicrob Agents Chemother. 64: PMID: 32513799
- New Drug Repositioning Candidates for T-ALL Identified Via Human/Murine Gene Signature Comparison. | Bonnet, R., et al. 2020. Front Oncol. 10: 557643. PMID: 33240808
- Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations. | Vallières, C., et al. 2021. Appl Microbiol Biotechnol. 105: 2867-2875. PMID: 33738552
- A high-throughput screen identifies inhibitors of lung cancer stem cells. | She, X., et al. 2021. Biomed Pharmacother. 140: 111748. PMID: 34044271
- Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells. | Fullerton, MS., et al. 2021. mSphere. 6: e0044221. PMID: 34232075
- Prochlorperazine Withdraws the Delayed Onset Tonic Activity of Unloaded Rat Soleus Muscle: A Pilot Study. | Kalashnikov, VE., et al. 2021. Life (Basel). 11: PMID: 34833037
- Application of Antisolvent Precipitation Method for Formulating Excipient-Free Nanoparticles of Psychotropic Drugs. | Wu, CY. and Wang, W. 2022. Pharmaceutics. 14: PMID: 35456653
- Perphenazine and prochlorperazine decrease glioblastoma U-87 MG cell migration and invasion: Analysis of the ABCB1 and ABCG2 transporters, E-cadherin, α-tubulin and integrins (α3, α5, and β1) levels. | Otręba, M., et al. 2022. Oncol Lett. 23: 182. PMID: 35527777
- Visualization of the photodegradation of a therapeutic drug by chemometric-assisted fluorescence spectroscopy. | Tanioka, M., et al. 2022. RSC Adv. 12: 20714-20720. PMID: 35919137
- The Food and Drug Administration-approved antipsychotic drug trifluoperazine, a calmodulin antagonist, inhibits viral replication through PERK-eIF2α axis. | Mao, Y., et al. 2022. Front Microbiol. 13: 979904. PMID: 36386620
- Phenotypic screening of 1,953 FDA-approved drugs reveals 26 hits with potential for repurposing for Peyronie's disease. | Ilg, MM., et al. 2022. PLoS One. 17: e0277646. PMID: 36508413
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prochlorperazine, dimaleate, 100 mg | sc-296136B | 100 mg | $20.00 | |||
Prochlorperazine, dimaleate, 1 g | sc-296136 | 1 g | $24.00 | |||
Prochlorperazine, dimaleate, 5 g | sc-296136A | 5 g | $71.00 |