Procaterol (CAS 72332-33-3)
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Procaterol is a potent β2-adrenergic agonist, distinguished by its ability to selectively stimulate β2-adrenergic receptors, leading to the relaxation of bronchial smooth muscle tissues. Its mechanism of action is primarily through the activation of adenylate cyclase, which in turn increases the intracellular concentration of cyclic adenosine monophosphate (cAMP). The elevated levels of cAMP result in the activation of protein kinase A (PKA), which then phosphorylates target proteins that cause smooth muscle relaxation and inhibit the release of pro-inflammatory mediators from mast cells. In research applications, procaterol serves as useful for studying the signaling pathways involved in β2-adrenergic receptor activation and the subsequent biological responses. This includes investigations into the mechanisms underlying bronchodilation, the modulation of immune cell activity, and the exploration of novel therapeutic targets for diseases characterized by bronchoconstriction and inflammatory responses.
Procaterol (CAS 72332-33-3) References
- Synergistic effect of theophylline and procaterol on interleukin-5-induced degranulation from human eosinophils. | Fujisawa, T., et al. 2002. J Asthma. 39: 21-7. PMID: 11883736
- Procaterol upregulates peroxisome proliferator-activated receptor-gamma expression in human eosinophils. | Ueki, S., et al. 2006. Int Arch Allergy Immunol. 140 Suppl 1: 35-41. PMID: 16772725
- Inhalation and incubation with procaterol increases diaphragm muscle contractility in mice. | Shindoh, C., et al. 2007. Allergol Int. 56: 285-91. PMID: 17646734
- Procaterol potentiates the anti-inflammatory activity of budesonide on eosinophil adhesion to lung fibroblasts. | Yoshida, N., et al. 2009. Int Arch Allergy Immunol. 150: 352-8. PMID: 19571567
- Procaterol inhibits lung fibroblast migration. | Kohyama, T., et al. 2009. Inflammation. 32: 387-92. PMID: 19728063
- Suppressive effects of procaterol on expression of IP-10/CXCL 10 and RANTES/CCL 5 by bronchial epithelial cells. | Lam, KP., et al. 2011. Inflammation. 34: 238-46. PMID: 20652827
- Effect of procaterol on Th2-related chemokines production in human monocyte and bronchial epithelial cells. | Huang, CH., et al. 2010. Pediatr Pulmonol. 45: 977-84. PMID: 20672293
- Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. | Yamaya, M., et al. 2011. Eur J Pharmacol. 650: 431-44. PMID: 20940011
- Procaterol-stimulated increases in ciliary bend amplitude and ciliary beat frequency in mouse bronchioles. | Komatani-Tamiya, N., et al. 2012. Cell Physiol Biochem. 29: 511-22. PMID: 22508058
- Treatment responses of procaterol and CD38 inhibitors in an ozone-induced airway hyperresponsiveness mice model. | Deng, Z., et al. 2013. Biol Pharm Bull. 36: 1348-55. PMID: 23902978
- Procaterol but not dexamethasone protects 16HBE cells from H₂O₂-induced oxidative stress. | Deng, Z., et al. 2014. J Pharmacol Sci. 125: 39-50. PMID: 24739282
- Pharmacokinetics of nebulized and oral procaterol in asthmatic and non-asthmatic subjects in relation to doping analysis. | Krogh, N., et al. 2016. Drug Test Anal. 8: 1056-1064. PMID: 26990656
- Responsiveness to bronchodilator procaterol in COPD as assessed by forced oscillation technique. | Ito, S., et al. 2017. Respir Physiol Neurobiol. 240: 41-47. PMID: 28238903
- Involvement of Allosteric Effect and KCa Channels in Crosstalk between β₂-Adrenergic and Muscarinic M₂ Receptors in Airway Smooth Muscle. | Kume, H., et al. 2018. Int J Mol Sci. 19: PMID: 29987243
- Ezrin knockdown reduces procaterol-stimulated ciliary beating without morphological changes in mouse airway cilia. | Kawaguchi, K., et al. 2022. J Cell Sci. 135: PMID: 35132996
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Procaterol, 100 mg | sc-344977 | 100 mg | $571.00 |