Date published: 2026-4-28

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Procarbazine Hydrochloride (CAS 366-70-1)

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Alternate Names:
Matulane
Application:
Procarbazine Hydrochloride is an antineoplastic agent
CAS Number:
366-70-1
Purity:
≥99%
Molecular Weight:
257.77
Molecular Formula:
C12H19N3O•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Procarbazine hydrochloride is a chemical compound that functions as an alkylating agent in and development settings. It acts by inhibiting DNA and RNA synthesis through alkylation of the DNA molecule, leading to the disruption of DNA replication and transcription processes. Procarbazine hydrochloride targets and cross-links DNA strands, interfering with the normal functioning of the genetic material. By inducing DNA damage, procarbazine hydrochloride disrupts the cell cycle and triggers apoptosis in rapidly dividing cells. Its mode of action involves the formation of DNA adducts, which ultimately leads to cell death. Procarbazine hydrochloride′s function in experimental involves its ability to induce DNA damage and interfere with cellular processes, making it a useful for studying the mechanisms of DNA damage and repair.


Procarbazine Hydrochloride (CAS 366-70-1) References

  1. The effect of enzyme-inducing antiseizure drugs on the pharmacokinetics and tolerability of procarbazine hydrochloride.  |  Grossman, SA., et al. 2006. Clin Cancer Res. 12: 5174-81. PMID: 16951236
  2. Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice.  |  Phonethepswath, S., et al. 2013. Environ Mol Mutagen. 54: 294-8. PMID: 23427001
  3. Integrated In Vivo Genotoxicity Assessment of Procarbazine Hydrochloride Demonstrates Induction of Pig-a and LacZ Mutations, and Micronuclei, in MutaMouse Hematopoietic Cells.  |  Maurice, C., et al. 2019. Environ Mol Mutagen. 60: 505-512. PMID: 30592561
  4. Regenerative medicine for male infertility: A focus on stem cell niche injury models.  |  Sagaradze, G., et al. 2022. Biomed J. 45: 607-614. PMID: 35123107
  5. N-methyl antitumour agents. A distinct class of anticancer drugs?  |  Newell, D., et al. 1987. Cancer Chemother Pharmacol. 19: 91-102. PMID: 3552281
  6. Impact on the survival of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio on prognosis in children with Hodgkin lymphoma.  |  Ertan, K., et al. 2022. Saudi Med J. 43: 451-457. PMID: 35537727
  7. The outcome of older adults with classic Hodgkin lymphoma in British Columbia.  |  Cheng, PTM., et al. 2022. Blood Adv. 6: 5924-5932. PMID: 36075016
  8. The Outcome of Hodgkin Lymphoma With Reference to Prognostic Markers.  |  Ahmed, R., et al. 2022. Cureus. 14: e28421. PMID: 36176827
  9. Recurrence of Angioimmunoblastic T-cell Lymphoma in a Patient Successfully Treated for Hodgkin's Lymphoma: A Case Report.  |  Nasir, SA., et al. 2022. Cureus. 14: e29867. PMID: 36348839
  10. Objective response rate targets for recurrent glioblastoma clinical trials based on the historic association between objective response rate and median overall survival.  |  Ellingson, BM., et al. 2023. Neuro Oncol. 25: 1017-1028. PMID: 36617262
  11. A Rare Case of Primary Anorectal Hodgkin Lymphoma in an HIV-Positive Patient: A Case Report and Literature Review.  |  Perez, FM., et al. 2023. Cureus. 15: e38796. PMID: 37303441
  12. Duplex sequencing provides detailed characterization of mutation frequencies and spectra in the bone marrow of MutaMouse males exposed to procarbazine hydrochloride.  |  Dodge, AE., et al. 2023. Arch Toxicol. 97: 2245-2259. PMID: 37341741

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Procarbazine Hydrochloride, 100 mg

sc-204862
100 mg
$84.00

Procarbazine Hydrochloride, 500 mg

sc-204862A
500 mg
$226.00